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Identifying New Hybrid Insulin Peptides (HIPs) in Type 1 Diabetes
In 2016 Delong et al. discovered a new type of neoepitope formed by the fusion of two unrelated peptide fragments. Remarkably these neoepitopes, called hybrid insulin peptides, or HIPs, are recognized by pathogenic CD4(+) T cells in the NOD mouse and human pancreatic islet-infiltrating T cells in pe...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Frontiers Media S.A.
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120023/ https://www.ncbi.nlm.nih.gov/pubmed/33995402 http://dx.doi.org/10.3389/fimmu.2021.667870 |