Defective NET clearance contributes to sustained FXII activation in COVID-19-associated pulmonary thrombo-inflammation

BACKGROUND: Coagulopathy and inflammation are hallmarks of Coronavirus disease 2019 (COVID-19) and are associated with increased mortality. Clinical and experimental data have revealed a role for neutrophil extracellular traps (NETs) in COVID-19 disease. The mechanisms that drive thrombo-inflammatio...

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Detalles Bibliográficos
Autores principales: Englert, Hanna, Rangaswamy, Chandini, Deppermann, Carsten, Sperhake, Jan-Peter, Krisp, Christoph, Schreier, Danny, Gordon, Emma, Konrath, Sandra, Haddad, Munif, Pula, Giordano, Mailer, Reiner K., Schlüter, Hartmut, Kluge, Stefan, Langer, Florian, Püschel, Klaus, Panousis, Kosta, Stavrou, Evi X., Maas, Coen, Renné, Thomas, Frye, Maike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2021
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120108/
https://www.ncbi.nlm.nih.gov/pubmed/34000623
http://dx.doi.org/10.1016/j.ebiom.2021.103382

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120108/
https://www.ncbi.nlm.nih.gov/pubmed/34000623
http://dx.doi.org/10.1016/j.ebiom.2021.103382

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