Nanopore direct RNA sequencing detects DUX4-activated repeats and isoforms in human muscle cells

Facioscapulohumeral muscular dystrophy (FSHD) is an inherited muscle disease caused by misexpression of the DUX4 gene in skeletal muscle. DUX4 is a transcription factor, which is normally expressed in the cleavage-stage embryo and regulates gene expression involved in early embryonic development. Re...

Descripción completa

Detalles Bibliográficos
Autores principales: Mitsuhashi, Satomi, Nakagawa, So, Sasaki-Honda, Mitsuru, Sakurai, Hidetoshi, Frith, Martin C, Mitsuhashi, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120133/
https://www.ncbi.nlm.nih.gov/pubmed/33693705
http://dx.doi.org/10.1093/hmg/ddab063

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120133/
https://www.ncbi.nlm.nih.gov/pubmed/33693705
http://dx.doi.org/10.1093/hmg/ddab063

Ejemplares similares