Humanization of a tandem repeat in IG-DMR causes stochastic restoration of paternal imprinting at mouse Dlk1-Dio3 domain

The Dlk1-Dio3 imprinted domain, regulated by an intergenic differentially methylated region (IG-DMR), is important for mammalian embryonic development. Although previous studies have reported that DNA methylation of a tandem repeated array sequence in paternal IG-DMR (IG-DMR-Rep) plays an essential...

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Detalles Bibliográficos
Autores principales: Hara, Satoshi, Terao, Miho, Tsuji-Hosokawa, Atsumi, Ogawa, Yuya, Takada, Shuji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120134/
https://www.ncbi.nlm.nih.gov/pubmed/33709141
http://dx.doi.org/10.1093/hmg/ddab071

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120134/
https://www.ncbi.nlm.nih.gov/pubmed/33709141
http://dx.doi.org/10.1093/hmg/ddab071

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