Combinatorial glucose, nicotinic acid and N-acetylcysteine therapy has synergistic effect in preclinical C. elegans and zebrafish models of mitochondrial complex I disease

Mitochondrial respiratory chain disorders are empirically managed with variable antioxidant, cofactor and vitamin ‘cocktails’. However, clinical trial validated and approved compounds, or doses, do not exist for any single or combinatorial mitochondrial disease therapy. Here, we sought to pre-clinic...

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Detalles Bibliográficos
Autores principales: Guha, Sujay, Mathew, Neal D, Konkwo, Chigoziri, Ostrovsky, Julian, Kwon, Young Joon, Polyak, Erzsebet, Seiler, Christoph, Bennett, Michael, Xiao, Rui, Zhang, Zhe, Nakamaru-Ogiso, Eiko, Falk, Marni J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
General Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120136/
https://www.ncbi.nlm.nih.gov/pubmed/33640978
http://dx.doi.org/10.1093/hmg/ddab059

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120136/
https://www.ncbi.nlm.nih.gov/pubmed/33640978
http://dx.doi.org/10.1093/hmg/ddab059

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