Mechanism of PKM2 affecting cancer immunity and metabolism in Tumor Microenvironment

PKM2 is the enzyme that regulates the final rate-limiting step of glycolysis. PKM2 expression can reinforce the utilization of oxygen and synthesis of growth substances in cancer cells by enhancing OXPHOS and the Warburg effect. In cancer immunity, PKM2 can modulate the expression of PD-L1 in M2 mac...

Descripción completa

Detalles Bibliográficos
Autores principales: Chen, Mengxi, Liu, Huan, Li, Zhang, Ming, Alex Lau, Chen, Honglei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120184/
https://www.ncbi.nlm.nih.gov/pubmed/33995634
http://dx.doi.org/10.7150/jca.54430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120184/
https://www.ncbi.nlm.nih.gov/pubmed/33995634
http://dx.doi.org/10.7150/jca.54430

Ejemplares similares