Cargando…

Mechanism of PKM2 affecting cancer immunity and metabolism in Tumor Microenvironment

PKM2 is the enzyme that regulates the final rate-limiting step of glycolysis. PKM2 expression can reinforce the utilization of oxygen and synthesis of growth substances in cancer cells by enhancing OXPHOS and the Warburg effect. In cancer immunity, PKM2 can modulate the expression of PD-L1 in M2 mac...

Descripción completa

Detalles Bibliográficos
Autores principales:	Chen, Mengxi, Liu, Huan, Li, Zhang, Ming, Alex Lau, Chen, Honglei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120184/ https://www.ncbi.nlm.nih.gov/pubmed/33995634 http://dx.doi.org/10.7150/jca.54430

Ejemplares similares

High expression of PKM2 synergizes with PD-L1 in tumor cells and immune cells to predict worse survival in human lung adenocarcinoma
por: Long, Long, et al.
Publicado: (2020)

The molecular mechanisms of LncRNA-correlated PKM2 in cancer metabolism
por: Tao, Ting, et al.
Publicado: (2019)

PKM2 Drives Hepatocellular Carcinoma Progression by Inducing Immunosuppressive Microenvironment
por: Li, Tian-En, et al.
Publicado: (2020)

PKM2 and cancer: The function of PKM2 beyond glycolysis
por: DONG, GAOCHAO, et al.
Publicado: (2016)

PKM2: The Thread Linking Energy Metabolism Reprogramming with Epigenetics in Cancer
por: Chen, Ling, et al.
Publicado: (2014)

PKM2 promotes reductive glutamine metabolism
por: Liu, Miao, et al.
Publicado: (2018)

52350 PKM2 mediates anti-tumor immunity and T cell dysfunction
por: Markowitz, Geoffrey, et al.
Publicado: (2021)

The promising immune checkpoint LAG-3: from tumor microenvironment to cancer immunotherapy
por: Long, Long, et al.
Publicado: (2018)

Research progress on the role of PKM2 in the immune response
por: Liu, Chunyan, et al.
Publicado: (2022)

PKM2, a Central Point of Regulation in Cancer Metabolism
por: Wong, Nicholas, et al.
Publicado: (2013)

Pyroptosis, metabolism, and tumor immune microenvironment
por: Du, Tiantian, et al.
Publicado: (2021)

Cancer-Associated Fibroblasts Affect Tumor Metabolism and Immune Microenvironment in Gastric Cancer and Identification of Its Characteristic Genes
por: Gao, Chanchan, et al.
Publicado: (2023)

PKM2, function and expression and regulation
por: Zhang, Ze, et al.
Publicado: (2019)

Diabetes and PKM2 affect prognosis in patients with intrahepatic cholangiocarcinoma
por: Fu, Kui, et al.
Publicado: (2020)

USP4 promotes the proliferation and glucose metabolism of gastric cancer cells by upregulating PKM2
por: Chen, Yuanyuan, et al.
Publicado: (2023)

Lactylation of PKM2 Suppresses Inflammatory Metabolic Adaptation in Pro-inflammatory Macrophages
por: Wang, Jizhuang, et al.
Publicado: (2022)

Efficacy and mechanism of combination of oxaliplatin with PKM2 knockdown in colorectal cancer
por: Yin, Chenxi, et al.
Publicado: (2020)

Structural insight into mechanisms for dynamic regulation of PKM2
por: Wang, Ping, et al.
Publicado: (2015)

PKM2 is not required for pancreatic ductal adenocarcinoma
por: Hillis, Alissandra L, et al.
Publicado: (2018)

Tyrosine Kinase Signaling in Cancer Metabolism: PKM2 Paradox in the Warburg Effect
por: Wiese, Elizabeth K., et al.
Publicado: (2018)

Correction to: PKM2, function and expression and regulation
por: Zhang, Ze, et al.
Publicado: (2019)

PKM2 is not required for colon cancer initiated by APC loss
por: Lau, Allison N., et al.
Publicado: (2017)

PKM2 in carcinogenesis and oncotherapy
por: He, Xia, et al.
Publicado: (2017)

The Role of PKM2 in the Regulation of Mitochondrial Function: Focus on Mitochondrial Metabolism, Oxidative Stress, Dynamic, and Apoptosis. PKM2 in Mitochondrial Function
por: Gao, Jing, et al.
Publicado: (2022)

Metabolic Hallmarks of Tumor and Immune Cells in the Tumor Microenvironment
por: Renner, Kathrin, et al.
Publicado: (2017)

Editorial: Metabolism of Cancer Cells and Immune Cells in the Tumor Microenvironment
por: Li, Yongsheng, et al.
Publicado: (2018)

A feedback loop between NONHSAT024276 and PTBP1 inhibits tumor progression and glycolysis in HCC by increasing the PKM1/PKM2 ratio
por: Li, Yuwei, et al.
Publicado: (2022)

PKM2 phosphorylates MLC2 and regulates cytokinesis of tumor cells
por: Jiang, Yuhui, et al.
Publicado: (2014)

Impacts and mechanisms of metabolic reprogramming of tumor microenvironment for immunotherapy in gastric cancer
por: Zhao, Lin, et al.
Publicado: (2022)

Down‐regulation of PKM2 enhances anticancer efficiency of THP on bladder cancer
por: Su, Qiongli, et al.
Publicado: (2018)

The Evasion Mechanisms of Cancer Immunity and Drug Intervention in the Tumor Microenvironment
por: Kim, Seong Keun, et al.
Publicado: (2022)

Unveiling tumor immune evasion mechanisms: abnormal expression of transporters on immune cells in the tumor microenvironment
por: Chen, Lu, et al.
Publicado: (2023)

Revisiting glucose metabolism in cancer: lessons from a PKM knock-in model
por: Sato, Taku, et al.
Publicado: (2018)

Competition for nutrients or cell intrinsic programming? – Metabolic mechanisms behind the tumor promoting immune microenvironment in cancer
por: Niu, Yuequn, et al.
Publicado: (2021)

Germline loss of PKM2 promotes metabolic distress and hepatocellular carcinoma
por: Dayton, Talya L., et al.
Publicado: (2016)

PKM and the maintenance of memory
por: Glanzman, David L.
Publicado: (2013)

Nanomedicines Targeting Metabolism in the Tumor Microenvironment
por: Ren, Mengdi, et al.
Publicado: (2022)

Iron Metabolism in the Tumor Microenvironment—Implications for Anti-Cancer Immune Response
por: Sacco, Alessandro, et al.
Publicado: (2021)

FOXM1D potentiates PKM2‐mediated tumor glycolysis and angiogenesis
por: Zhang, Wei, et al.
Publicado: (2021)

Lipid metabolic reprogramming in tumor microenvironment: from mechanisms to therapeutics
por: Jin, Hao-Ran, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_d8q18vb9mp21fc5g4bi9q2pumr