Cargando…

Longitudinal evaluation of a novel BChE PET tracer as an early in vivo biomarker in the brain of a mouse model for Alzheimer disease

Purpose: The increase in butyrylcholinesterase (BChE) activity in the brain of Alzheimer disease (AD) patients and animal models of AD position this enzyme as a potential biomarker of the disease. However, the information on the ability of BChE to serve as AD biomarker is contradicting, also due to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Rejc, Luka, Gómez-Vallejo, Vanessa, Joya, Ana, Moreno, Oscar, Egimendia, Ander, Castellnou, Pilar, Ríos-Anglada, Xabier, Cossío, Unai, Baz, Zuriñe, Passannante, Rossana, Tobalina-Larrea, Ignacio, Ramos-Cabrer, Pedro, Giralt, Albert, Sastre, Magdalena, Capetillo-Zarate, Estibaliz, Košak, Urban, Knez, Damijan, Gobec, Stanislav, Marder, Mariel, Martin, Abraham, Llop, Jordi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2021
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120209/ https://www.ncbi.nlm.nih.gov/pubmed/33995675 http://dx.doi.org/10.7150/thno.54589

Ejemplares similares

Longitudinal evaluation of neuroinflammation and oxidative stress in a mouse model of Alzheimer disease using positron emission tomography
por: Rejc, Luka, et al.
Publicado: (2022)

Novel Sulfonamide-Based Carbamates as Selective Inhibitors of BChE
por: Magar, Pratibha, et al.
Publicado: (2021)

Biphasic Alteration of Butyrylcholinesterase (BChE) During Prostate Cancer Development
por: Gu, Yan, et al.
Publicado: (2018)

Characterization of the Transient Oxaphosphetane BChE Inhibitor Formed from Spontaneously Activated Ethephon
por: Lantz, Stephen R., et al.
Publicado: (2013)

Gestational diabetes mellitus (GDM) decreases butyrylcholinesterase (BChE) activity and changes its relationship with lipids
por: Guimarães, Larissa O., et al.
Publicado: (2014)

Discovery of Selective Butyrylcholinesterase (BChE) Inhibitors through a Combination of Computational Studies and Biological Evaluations
por: Zhou, You, et al.
Publicado: (2019)

Preoperative BChE serves as a prognostic marker in patients with resectable AEG after neoadjuvant chemotherapy
por: Gensthaler, Lisa, et al.
Publicado: (2023)

SAR-mediated Similarity Assessment of the Property Profile for New, Silicon-Based AChE/BChE Inhibitors
por: Bak, Andrzej, et al.
Publicado: (2019)

Extending the lore of curcumin as dipteran Butyrylcholine esterase (BChE) inhibitor: A holistic molecular interplay assessment
por: Rao, Priyashi, et al.
Publicado: (2022)

Biochemical and genetic analysis of butyrylcholinesterase (BChE) in a family, due to prolonged neuromuscular blockade after the use of succinylcholine
por: Garcia, Daniel Fantozzi, et al.
Publicado: (2011)

Novel Benzene-Based Carbamates for AChE/BChE Inhibition: Synthesis and Ligand/Structure-Oriented SAR Study
por: Bak, Andrzej, et al.
Publicado: (2019)

Differences in plasmatic butyrylcholinesterases (BChE) values between Pacific and Caribbean populations of terciopelo (Bothrops asper) in Costa Rica
por: Arguedas, Randall, et al.
Publicado: (2019)

In Vitro and In Silico Investigation of Polyacetylenes from Launaea capitata (Spreng.) Dandy as Potential COX-2, 5-LOX, and BchE Inhibitors
por: Abdel Bar, Fatma M., et al.
Publicado: (2023)

Enhanced Contextual Fear Memory and Elevated Astroglial Glutamate Synthase Activity in Hippocampal CA1 BChE shRNA Knockdown Mice
por: Chen, Si, et al.
Publicado: (2020)

Discovery of New Selective Butyrylcholinesterase (BChE) Inhibitors with Anti-Aβ Aggregation Activity: Structure-Based Virtual Screening, Hit Optimization and Biological Evaluation
por: Jiang, Cheng-Shi, et al.
Publicado: (2019)

In silico modeling of the specific inhibitory potential of thiophene-2,3-dihydro-1,5-benzothiazepine against BChE in the formation of β-amyloid plaques associated with Alzheimer's disease
por: Ul-Haq, Zaheer, et al.
Publicado: (2010)

Acorenone B: AChE and BChE Inhibitor as a Major Compound of the Essential Oil Distilled from the Ecuadorian Species Niphogeton dissecta (Benth.) J.F. Macbr
por: Calva, James, et al.
Publicado: (2017)

Synthesis and Initial Characterization of a Reversible, Selective (18)F-Labeled Radiotracer for Human Butyrylcholinesterase
por: Gentzsch, Christian, et al.
Publicado: (2021)

Design, synthesis, crystal structure, in vitro cytotoxicity evaluation, density functional theory calculations and docking studies of 2-(benzamido) benzohydrazide derivatives as potent AChE and BChE inhibitors
por: Kausar, Naghmana, et al.
Publicado: (2021)

Screening of Big Pharma’s Library against Various in-house Biological Targets
por: Knez, Damijan, et al.
Publicado: (2022)

Overexpression of a carrot BCH gene, DcBCH1, improves tolerance to drought in Arabidopsis thaliana
por: Li, Tong, et al.
Publicado: (2021)

Analysis of Blind Reconstruction of BCH Codes
por: Kwon, Soonhee, et al.
Publicado: (2020)

Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes
por: Pajk, Stane, et al.
Publicado: (2020)

4-Phenethyl-1-Propargylpiperidine-Derived Dual Inhibitors of Butyrylcholinesterase and Monoamine Oxidase B
por: Mazej, Tjaša, et al.
Publicado: (2021)

Obesity and variants of the GHRL (ghrelin) and BCHE (butyrylcholinesterase) genes
por: Dantas, Vitor G.L., et al.
Publicado: (2011)

Gold Nanoparticles as Boron Carriers for Boron Neutron Capture Therapy: Synthesis, Radiolabelling and In Vivo Evaluation
por: Pulagam, Krishna R., et al.
Publicado: (2019)

Exploring the role of BCHE in the onset of Diabetes, Obesity and Neurological Disorders
por: Rao, Allam Appa, et al.
Publicado: (2012)

Some New Quantum BCH Codes over Finite Fields
por: Xing, Lijuan, et al.
Publicado: (2021)

Biological Evaluation of Valeriana Extracts from Argentina with Potent Cholinesterase Inhibition for the Treatment of Neurodegenerative Disorders and Their Comorbidities—The Case of Valeriana carnosa Sm. (Caprifoliaceae) Studied in Mice
por: Marcucci, Carolina, et al.
Publicado: (2023)

Citrus β-carotene hydroxylase 2 (BCH2) participates in xanthophyll synthesis by catalyzing the hydroxylation of β-carotene and compensates for BCH1 in citrus carotenoid metabolism
por: Zhang, Yingzi, et al.
Publicado: (2022)

Effect of BCHE single nucleotide polymorphisms on lipid metabolism markers in women
por: de Oliveira, Jéssica, et al.
Publicado: (2017)

BCHE as a Prognostic Biomarker in Endometrial Cancer and Its Correlation with Immunity
por: Liu, Junxiu, et al.
Publicado: (2022)

Unpredictable Nanoparticle Retention in Commonly Used Plastic Syringes Introduces Dosage Uncertainties That May Compromise the Accuracy of Nanomedicine and Nanotoxicology Studies
por: Holzwarth, Uwe, et al.
Publicado: (2019)

Differential hydroxylation efficiency of the two non-heme carotene hydroxylases: DcBCH1, rather than DcBCH2, plays a major role in carrot taproot
por: Li, Tong, et al.
Publicado: (2022)

Aging Reduces the Functional Brain Networks Strength—a Resting State fMRI Study of Healthy Mouse Brain
por: Egimendia, Ander, et al.
Publicado: (2019)

Fragment-Sized Thiazoles in Fragment-Based Drug Discovery Campaigns: Friend or Foe?
por: Proj, Matic, et al.
Publicado: (2022)

In vivo multimodal imaging of adenosine A(1) receptors in neuroinflammation after experimental stroke
por: Joya, Ana, et al.
Publicado: (2021)

Robert Roxburgh, M.B., B.Ch., F.R.C.S.E.
Publicado: (1917)

Investigation of Association between Susceptibility to Leprosy and SNPs inside and near the BCHE Gene of Butyrylcholinesterase
por: Gomes, Henrique J. P., et al.
Publicado: (2012)

The rs1803274 polymorphism of the BCHE gene is associated with an increased risk of coronary in-stent restenosis
por: Pleva, L., et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_74393r2a8nlg5pr6mt72674cbt