Cargando…

Crocetin and Its Glycoside Crocin, Two Bioactive Constituents From Crocus sativus L. (Saffron), Differentially Inhibit Angiogenesis by Inhibiting Endothelial Cytoskeleton Organization and Cell Migration Through VEGFR2/SRC/FAK and VEGFR2/MEK/ERK Signaling Pathways

Crocetin and crocin are two important carotenoids isolated from saffron (Crocus sativus L.), which have been used as natural biomedicines with beneficial effects for improving the suboptimal health status associated with abnormal angiogenesis. However, the anti-angiogenic effects and underlying mech...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Chen, Kam, Hio-Tong, Chen, Yan, Gong, Guiyi, Hoi, Maggie Pui-Man, Skalicka-Woźniak, Krystyna, Dias, Alberto Carlos Pires, Lee, Simon Ming-Yuen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2021
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120304/ https://www.ncbi.nlm.nih.gov/pubmed/33995106 http://dx.doi.org/10.3389/fphar.2021.675359

Ejemplares similares

Changes of Crocin and Other Crocetin Glycosides in Saffron Through Cooking Models, and Discovery of Rare Crocetin Glycosides in the Yellow Flowers of Freesia Hybrida
por: Shindo, Kazutoshi, et al.
Publicado: (2022)

Safety evaluation of saffron stigma (Crocus sativus L.) aqueous extract and crocin in patients with schizophrenia
por: Mousavi, Bentolhoda, et al.
Publicado: (2015)

UHPLC Analysis of Saffron (Crocus sativus L.): Optimization of Separation Using Chemometrics and Detection of Minor Crocetin Esters
por: D’Archivio, Angelo Antonio, et al.
Publicado: (2018)

Saffron (Crocus sativus L.): As an Antidepressant
por: Siddiqui, Mohammad J., et al.
Publicado: (2018)

The Efficacy of Crocin of Saffron (Crocus sativus L.) on the Components of Metabolic Syndrome: A Randomized Controlled Clinical Trial
por: Kermani, Tayyebe, et al.
Publicado: (2017)

Effects of Crocetin Esters and Crocetin from Crocus sativus L. on Aortic Contractility in Rat Genetic Hypertension
por: Llorens, Silvia, et al.
Publicado: (2015)

Crocus Sativus L. (Saffron) Extract and its Active Constituents (Crocin and Safranal) on Ischemia-Reperfusion in Rat Skeletal Muscle
por: Hosseinzadeh, Hossein, et al.
Publicado: (2009)

The Crocus sativus Compounds trans-Crocin 4 and trans-Crocetin Modulate the Amyloidogenic Pathway and Tau Misprocessing in Alzheimer Disease Neuronal Cell Culture Models
por: Chalatsa, Ioanna, et al.
Publicado: (2019)

Anticarcinogenic effect of saffron (Crocus sativus L.) and its ingredients
por: Samarghandian, Saeed, et al.
Publicado: (2014)

Razi’s Al-Hawi and saffron (Crocus sativus): a review
por: Mollazadeh, Hamid, et al.
Publicado: (2015)

Transcriptome profiling of the flowering transition in saffron (Crocus sativus L.)
por: Hu, Jing, et al.
Publicado: (2020)

Therapeutic Potential of Saffron (Crocus sativus L.) in Ischemia Stroke
por: Azami, Shakiba, et al.
Publicado: (2021)

The Effect of the Crocus Sativus L. Carotenoid, Crocin, on the Polymerization of Microtubules, in Vitro
por: Zarei Jaliani, Hossein, et al.
Publicado: (2013)

Effect of Crocus sativus L. Stigmas Microwave Dehydration on Picrocrocin, Safranal and Crocetin Esters
por: García-Blázquez, Aarón, et al.
Publicado: (2021)

AFLP and MS-AFLP Analysis of the Variation within Saffron Crocus (Crocus sativus L.) Germplasm
por: Busconi, Matteo, et al.
Publicado: (2015)

Epigenetic Variability Among Saffron Crocus (Crocus sativus L.) Accessions Characterized by Different Phenotypes
por: Busconi, Matteo, et al.
Publicado: (2021)

Crocus sativus L. (saffron) for cancer chemoprevention: A mini review
por: Bhandari, Prasan R.
Publicado: (2015)

Could Crocus sativus (saffron) be combined with conventional therapies for ocular diseases?
por: Bhandari, Prasan R
Publicado: (2015)

Hormone and Microorganism Treatments in the Cultivation of Saffron (Crocus Sativus L.) Plants
por: Aytekin, Alper, et al.
Publicado: (2008)

Bioaccessibility and Pharmacokinetics of a Commercial Saffron (Crocus sativus L.) Extract
por: Almodóvar, Paula, et al.
Publicado: (2020)

Injury and not the pathogen is the primary cause of corm rot in Crocus sativus (saffron)
por: Mansotra, Ritika, et al.
Publicado: (2023)

Comparative Study on The Preventive Effect of Saffron Carotenoids, Crocin and Crocetin, in NMU-Induced Breast Cancer in Rats
por: Sajjadi, Meysam, et al.
Publicado: (2017)

The effects of Crocus sativus (saffron) and its constituents on nervous system: A review
por: Khazdair, Mohammad Reza, et al.
Publicado: (2015)

Therapeutic effects of saffron (Crocus sativus L.) in digestive disorders: a review
por: Khorasany, Alireza Rezaee, et al.
Publicado: (2016)

Saffron (Crocus sativus) petal as a new pharmacological target: a review
por: Hosseini, Azar, et al.
Publicado: (2018)

Electrocardiogram alterations following one-week consumption of Crocus sativus L. (Saffron)
por: Joukar, Siyavash
Publicado: (2012)

The Relation between Drying Conditions and the Development of Volatile Compounds in Saffron (Crocus sativus)
por: Cid-Pérez, Teresa Soledad, et al.
Publicado: (2021)

Effect of Soil Composition on Secondary Metabolites of Moroccan Saffron (Crocus sativus L.)
por: Chaouqi, Soukaina, et al.
Publicado: (2023)

Fingerprint of Characteristic Saffron Compounds as Novel Standardization of Commercial Crocus sativus Extracts
por: Mena-García, Adal, et al.
Publicado: (2023)

A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents
por: Anaeigoudari, Fatemeh, et al.
Publicado: (2023)

Crocins from Crocus sativus L. in the Management of Hyperglycemia. In Vivo Evidence from Zebrafish
por: Kakouri, Eleni, et al.
Publicado: (2020)

Effects of Saffron (Crocus sativus L.) Stigma Extract and its Active Constituent Crocin on Neuropathic Pain Responses in a Rat Model of Chronic Constriction Injury
por: Safakhah, Hossein Ali, et al.
Publicado: (2016)

A New Glycosyltransferase Enzyme from Family 91, UGT91P3, Is Responsible for the Final Glucosylation Step of Crocins in Saffron (Crocus sativus L.)
por: López-jimenez, Alberto José, et al.
Publicado: (2021)

Study on diuretic activity of saffron (stigma of Crocus sativus L.) Aqueous extract in rat
por: Shariatifar, Nabi, et al.
Publicado: (2014)

Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms
por: Mokhtari-Zaer, Amin, et al.
Publicado: (2015)

Comparative evaluation of extraction methods for total proteins from Crocus sativus L. (Saffron)
por: Mehraj, Syed Sana, et al.
Publicado: (2018)

Constituents of Saffron (Crocus sativus L.) as Potential Candidates for the Treatment of Anxiety Disorders and Schizophrenia
por: Pitsikas, Nikolaos
Publicado: (2016)

Smooth muscle relaxant activity of Crocus sativus (saffron) and its constituents: possible mechanisms
por: Gorginzadeh, Mansoureh, et al.
Publicado: (2018)

Antianhedonic and Antidepressant Effects of Affron(®), a Standardized Saffron (Crocus Sativus L.) Extract
por: Orio, Laura, et al.
Publicado: (2020)

A Review of Potential Efficacy of Saffron (Crocus sativus L.) in Cognitive Dysfunction and Seizures
por: Rajabian, Arezoo, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_64smaa8ma2ust75p84t13gjb42