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pHLARE: a new biosensor reveals decreased lysosome pH in cancer cells

Many lysosome functions are determined by a lumenal pH of ∼5.0, including the activity of resident acid-activated hydrolases. Lysosome pH (pHlys) is often increased in neurodegenerative disorders and predicted to be decreased in cancers, making it a potential target for therapeutics to limit the pro...

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Detalles Bibliográficos
Autores principales: Webb, Bradley A., Aloisio, Francesca M., Charafeddine, Rabab A., Cook, Jessica, Wittmann, Torsten, Barber, Diane L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society for Cell Biology 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120692/
https://www.ncbi.nlm.nih.gov/pubmed/33237838
http://dx.doi.org/10.1091/mbc.E20-06-0383