Cargando…

Fargesin ameliorates osteoarthritis via macrophage reprogramming by downregulating MAPK and NF-κB pathways

BACKGROUND: To investigate the role and regulatory mechanisms of fargesin, one of the main components of Magnolia fargesii, in macrophage reprogramming and crosstalk across cartilage and synovium during osteoarthritis (OA) development. METHODS: Ten-week-old male C57BL/6 mice were randomized and assi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Jiansen, Zhang, Hongbo, Pan, Jianying, Hu, Zhiqiang, Liu, Liangliang, Liu, Yanli, Yu, Xiao, Bai, Xiaochun, Cai, Daozhang, Zhang, Haiyan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120707/ https://www.ncbi.nlm.nih.gov/pubmed/33990219 http://dx.doi.org/10.1186/s13075-021-02512-z

Ejemplares similares

MFG-E8 regulated by miR-99b-5p protects against osteoarthritis by targeting chondrocyte senescence and macrophage reprogramming via the NF-κB pathway
por: Lu, Yuheng, et al.
Publicado: (2021)

Pseudolaric acid B ameliorates synovial inflammation and vessel formation by stabilizing PPARγ to inhibit NF‐κB signalling pathway
por: Lu, Jiansen, et al.
Publicado: (2021)

BMP5 silencing inhibits chondrocyte senescence and apoptosis as well as osteoarthritis progression in mice
por: Shao, Yan, et al.
Publicado: (2021)

Pentraxin 3 regulated by miR-224-5p modulates macrophage reprogramming and exacerbates osteoarthritis associated synovitis by targeting CD32
por: Yin, Jianbin, et al.
Publicado: (2022)

Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR
por: Feng, Xiaofeng, et al.
Publicado: (2020)

MiR-146b accelerates osteoarthritis progression by targeting alpha-2-macroglobulin
por: Liu, Xin, et al.
Publicado: (2019)

Anti-Inflammatory Effects of Fargesin on Chemically Induced Inflammatory Bowel Disease in Mice
por: Yue, Bei, et al.
Publicado: (2018)

Down-regulated GAS6 impairs synovial macrophage efferocytosis and promotes obesity-associated osteoarthritis
por: Yao, Zihao, et al.
Publicado: (2023)

Ononin ameliorates inflammation and cartilage degradation in rat chondrocytes with IL-1β-induced osteoarthritis by downregulating the MAPK and NF-κB pathways
por: Xu, Fang, et al.
Publicado: (2022)

Cepharanthine Ameliorates Chondrocytic Inflammation and Osteoarthritis via Regulating the MAPK/NF-κB-Autophagy Pathway
por: Yao, Minjun, et al.
Publicado: (2022)

Flos magnoliae constituent fargesin has an anti-allergic effect via ORAI1 channel inhibition
por: Hong, Phan Thi Lam, et al.
Publicado: (2021)

Carbon dots derived from folic acid attenuates osteoarthritis by protecting chondrocytes through NF-κB/MAPK pathway and reprogramming macrophages
por: Jin, Yu, et al.
Publicado: (2022)

Ojeoksan Ameliorates Cisplatin-Induced Acute Kidney Injury in Mice by Downregulating MAPK and NF-κB Pathways
por: Kim, Dong-Uk, et al.
Publicado: (2022)

Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12
por: Lin, Chuangxin, et al.
Publicado: (2019)

Fructose-bisphosphatase1 (FBP1) alleviates experimental osteoarthritis by regulating Protein crumbs homolog 3 (CRB3)
por: Wang, Zhuolun, et al.
Publicado: (2023)

Schisandrin B ameliorated chondrocytes inflammation and osteoarthritis via suppression of NF-κB and MAPK signal pathways
por: Ran, Jisheng, et al.
Publicado: (2018)

Correction to: Activation of mTORC1 in subchondral bone preosteoblasts promotes osteoarthritis by stimulating bone sclerosis and secretion of CXCL12
por: Lin, Chuangxin, et al.
Publicado: (2019)

Parthenolide Is Neuroprotective in Rat Experimental Stroke Model: Downregulating NF-κB, Phospho-p38MAPK, and Caspase-1 and Ameliorating BBB Permeability
por: Dong, Lipeng, et al.
Publicado: (2013)

Inhibitory Effects of Dimethyllirioresinol, Epimagnolin A, Eudesmin, Fargesin, and Magnolin on Cytochrome P450 Enzyme Activities in Human Liver Microsomes
por: Kim, Ju-Hyun, et al.
Publicado: (2017)

Anemoside B4 ameliorates TNBS-induced colitis through S100A9/MAPK/NF-κB signaling pathway
por: Zhang, Yong, et al.
Publicado: (2021)

Fargesin Inhibits EGF-Induced Cell Transformation and Colon Cancer Cell Growth by Suppression of CDK2/Cyclin E Signaling Pathway
por: Lee, Ga-Eun, et al.
Publicado: (2021)

Phillygenin inhibits inflammation in chondrocytes via the Nrf2/NF-κB axis and ameliorates osteoarthritis in mice
por: Zhang, Peng, et al.
Publicado: (2023)

Specific PFKFB3 Inhibitor Memorably Ameliorates Intervertebral Disc Degeneration via Inhibiting NF-κB and MAPK Signaling Pathway and Reprogramming of Energy Metabolism of Nucleus Pulposus Cells
por: Cao, Xiankun, et al.
Publicado: (2022)

Chondro-Protective Effects of Shikimic Acid on Osteoarthritis via Restoring Impaired Autophagy and Suppressing the MAPK/NF-κB Signaling Pathway
por: You, Hongbo, et al.
Publicado: (2021)

α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice
por: Zhang, Huawei, et al.
Publicado: (2021)

In Vitro and In Vivo Anti-Inflammatory Effects of Polyphyllin VII through Downregulating MAPK and NF-κB Pathways
por: Zhang, Chao, et al.
Publicado: (2019)

Down-regulation of protease-activated receptor 2 ameliorated osteoarthritis in rats through regulation of MAPK/NF-κB signaling pathway in vivo and in vitro
por: Yan, Shichang, et al.
Publicado: (2020)

Cimifugin ameliorates imiquimod-induced psoriasis by inhibiting oxidative stress and inflammation via NF-κB/MAPK pathway
por: Liu, Aimin, et al.
Publicado: (2020)

Corilagin ameliorates macrophages inflammation in atherosclerosis through TLR4-NFκB/MAPK pathway
por: Meng, Da, et al.
Publicado: (2023)

MicroRNA-186-5p downregulation inhibits osteoarthritis development by targeting MAPK1
por: Li, Qing, et al.
Publicado: (2021)

Anhuienoside C Ameliorates Collagen-Induced Arthritis through Inhibition of MAPK and NF-κB Signaling Pathways
por: Liu, Qing, et al.
Publicado: (2017)

Tetrahydrofurofuranoid Lignans, Eudesmin, Fargesin, Epimagnolin A, Magnolin, and Yangambin Inhibit UDP-Glucuronosyltransferase 1A1 and 1A3 Activities in Human Liver Microsomes
por: Park, Ria, et al.
Publicado: (2021)

Wang-Bi Tablet Ameliorates DMM-Induced Knee Osteoarthritis through Suppressing the Activation of p38-MAPK and NF-κB Signaling Pathways in Mice
por: Li, Hui, et al.
Publicado: (2021)

Rutaecarpine ameliorates osteoarthritis by inhibiting PI3K/AKT/NF-κB and MAPK signalling transduction through integrin αVβ3
por: Wan, Junlai, et al.
Publicado: (2023)

Salidroside Ameliorates Renal Interstitial Fibrosis by Inhibiting the TLR4/NF-κB and MAPK Signaling Pathways
por: Li, Rui, et al.
Publicado: (2019)

Downregulating p22phox ameliorates inflammatory response in Angiotensin II-induced oxidative stress by regulating MAPK and NF-κB pathways in ARPE-19 cells
por: Qiu, Yiguo, et al.
Publicado: (2015)

Catalpol ameliorates psoriasis-like phenotypes via SIRT1 mediated suppression of NF-κB and MAPKs signaling pathways
por: Liu, Aimin, et al.
Publicado: (2020)

Paeonol Ameliorates Ovalbumin-Induced Asthma through the Inhibition of TLR4/NF-κB and MAPK Signaling
por: Tang, Yongjun, et al.
Publicado: (2018)

Maslinic Acid Ameliorates Inflammation via the Downregulation of NF-κB and STAT-1
por: Lee, Wonhwa, et al.
Publicado: (2020)

Lipopolysaccharide-Binding Protein Downregulates Fractalkine through Activation of p38 MAPK and NF-κB
por: Huang, Xia, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_grjta0l975n10m4n2hklds4fgh