AKT-mediated phosphorylation of Sox9 induces Sox10 transcription in a murine model of HER2-positive breast cancer

BACKGROUND: Approximately 5–10% of HER2-positive breast cancers can be defined by low expression of the Ste20-like kinase, SLK, and high expression of SOX10. Our lab has observed that genetic deletion of SLK results in the induction of Sox10 and significantly accelerates tumor initiation in a HER2-i...

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Detalles Bibliográficos
Autores principales: Al-Zahrani, Khalid N., Abou-Hamad, John, Pascoal, Julia, Labrèche, Cédrik, Garland, Brennan, Sabourin, Luc A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120776/
https://www.ncbi.nlm.nih.gov/pubmed/33985544
http://dx.doi.org/10.1186/s13058-021-01435-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120776/
https://www.ncbi.nlm.nih.gov/pubmed/33985544
http://dx.doi.org/10.1186/s13058-021-01435-6

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