Cargando…

METTL13 inhibits progression of clear cell renal cell carcinoma with repression on PI3K/AKT/mTOR/HIF-1α pathway and c-Myc expression

BACKGROUND: Clear cell renal cell carcinoma (ccRCC) is the most common and aggressive type of renal malignancy. Methyltransferase like 13 (METTL13) functions as an oncogene in most of human cancers, but its function and mechanism in ccRCC remains unreported. METHODS: qRT-PCR, western blotting and im...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Zhuonan, Sun, Tianshui, Piao, Chiyuan, Zhang, Zhe, Kong, Chuize
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2021
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120818/ https://www.ncbi.nlm.nih.gov/pubmed/33985542 http://dx.doi.org/10.1186/s12967-021-02879-2

Ejemplares similares

METTL14-mediated N(6)-methyladenosine modification of ITGB4 mRNA inhibits metastasis of clear cell renal cell carcinoma
por: Liu, Zhuonan, et al.
Publicado: (2022)

The Sigma‐2 Receptor/TMEM97 Agonist PB28 Suppresses Cell Proliferation and Invasion by Regulating the PI3K‐AKT‐mTOR Signalling Pathway in Renal Cancer
por: Zhan, Bo, et al.
Publicado: (2021)

Flavokawain A is a natural inhibitor of PRMT5 in bladder cancer
por: Liu, Shuangjie, et al.
Publicado: (2022)

FAP promotes clear cell renal cell carcinoma progression via activating the PI3K/AKT/mTOR signaling pathway
por: Jiang, Kun, et al.
Publicado: (2023)

RUNX2 interacts with SCD1 and activates Wnt/β‐catenin signaling pathway to promote the progression of clear cell renal cell carcinoma
por: Song, Xiandong, et al.
Publicado: (2022)

TMEM119 facilitates ovarian cancer cell proliferation, invasion, and migration via the PDGFRB/PI3K/AKT signaling pathway
por: Sun, Tianshui, et al.
Publicado: (2021)

Inhibition of Aerobic Glycolysis Represses Akt/mTOR/HIF-1α Axis and Restores Tamoxifen Sensitivity in Antiestrogen-Resistant Breast Cancer Cells
por: Woo, Yu Mi, et al.
Publicado: (2015)

FBXO30 functions as a tumor suppressor and an E3 ubiquitin ligase for hZIP1-mediated HIF-1α degradation in renal cell carcinoma
por: Yuan, Yulin, et al.
Publicado: (2023)

MYC Cooperates with AKT in Prostate Tumorigenesis and Alters Sensitivity to mTOR Inhibitors
por: Clegg, Nicola J., et al.
Publicado: (2011)

Naringin inhibits colorectal cancer cell growth by repressing the PI3K/AKT/mTOR signaling pathway
por: Cheng, Hongyun, et al.
Publicado: (2020)

Prognostic significance of PI3K/AKT/ mTOR signaling pathway members in clear cell renal cell carcinoma
por: Fan, Demin, et al.
Publicado: (2020)

m(6)A methyltransferase METTL3 promotes retinoblastoma progression via PI3K/AKT/mTOR pathway
por: Zhang, Han, et al.
Publicado: (2020)

Gypenosides Attenuate Pulmonary Fibrosis by Inhibiting the AKT/mTOR/c-Myc Pathway
por: Liu, Suqing, et al.
Publicado: (2022)

mTOR Regulation of N-Myc Downstream Regulated 1 (NDRG1) Phosphorylation in Clear Cell Renal Cell Carcinoma
por: Valluri, Anisha, et al.
Publicado: (2023)

The m6A methyltransferase METTL14 inhibits the proliferation, migration, and invasion of gastric cancer by regulating the PI3K/AKT/mTOR signaling pathway
por: Liu, Xin, et al.
Publicado: (2020)

YTHDF1 Promotes Bladder Cancer Cell Proliferation via the METTL3/YTHDF1–RPN2–PI3K/AKT/mTOR Axis
por: Zhu, Junlong, et al.
Publicado: (2023)

Brassinin Represses Invasive Potential of Lung Carcinoma Cells through Deactivation of PI3K/Akt/mTOR Signaling Cascade
por: Yang, Min Hee, et al.
Publicado: (2019)

WTD Attenuating Rheumatoid Arthritis via Suppressing Angiogenesis and Modulating the PI3K/AKT/mTOR/HIF-1α Pathway
por: Ba, Xin, et al.
Publicado: (2021)

Bromocriptine and cabergoline induce cell death in prolactinoma cells via the ERK/EGR1 and AKT/mTOR pathway respectively
por: Tang, Chao, et al.
Publicado: (2019)

METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion
por: Zhang, Zhe, et al.
Publicado: (2016)

Akt and mTOR in B Cell Activation and Differentiation
por: Limon, Jose J., et al.
Publicado: (2012)

PI3K/AKT/mTOR Dysregulation and Reprogramming Metabolic Pathways in Renal Cancer: Crosstalk with the VHL/HIF Axis
por: Badoiu, Silviu Constantin, et al.
Publicado: (2023)

Overexpression of UNC5B in bladder cancer cells inhibits proliferation and reduces the volume of transplantation tumors in nude mice
por: Kong, Chuize, et al.
Publicado: (2016)

Suppression of PI3K/Akt/mTOR/c-Myc/mtp53 Positive Feedback Loop Induces Cell Cycle Arrest by Dual PI3K/mTOR Inhibitor PQR309 in Endometrial Cancer Cell Lines
por: Hsin, I-Lun, et al.
Publicado: (2021)

UCHL5 Promotes Proliferation and Migration of Bladder Cancer Cells by Activating c-Myc via AKT/mTOR Signaling
por: Cao, Yuanfei, et al.
Publicado: (2022)

PI3K/AKT/mTOR Pathway in Angiogenesis
por: Karar, Jayashree, et al.
Publicado: (2011)

Dysregulation in Akt/mTOR/HIF-1 signaling identified by proteo-transcriptomics of SARS-CoV-2 infected cells
por: Appelberg, Sofia, et al.
Publicado: (2020)

mTOR-Related Cell-Clearing Systems in Epileptic Seizures, an Update
por: Limanaqi, Fiona, et al.
Publicado: (2020)

STIL Promotes Tumorigenesis of Bladder Cancer by Activating PI3K/AKT/mTOR Signaling Pathway and Targeting C-Myc
por: Yu, Hua, et al.
Publicado: (2022)

Galectin-1 has potential prognostic significance and is implicated in clear cell renal cell carcinoma progression through the HIF/mTOR signaling axis
por: White, N M A, et al.
Publicado: (2014)

Galectin-1 has potential prognostic significance and is implicated in clear cell renal cell carcinoma progression through the HIF/mTOR signaling axis
por: White, N M A, et al.
Publicado: (2017)

Berberine Improves Chemo-Sensitivity to Cisplatin by Enhancing Cell Apoptosis and Repressing PI3K/AKT/mTOR Signaling Pathway in Gastric Cancer
por: Kou, Yingying, et al.
Publicado: (2020)

Retraction Note: METTL13 is downregulated in bladder carcinoma and suppresses cell proliferation, migration and invasion
por: Zhang, Zhe, et al.
Publicado: (2023)

The Paradox of Akt-mTOR Interactions
por: Vadlakonda, Lakshmipathi, et al.
Publicado: (2013)

Hydroxytyrosol Alleviated Hypoxia-Mediated PC12 Cell Damage through Activating PI3K/AKT/mTOR-HIF-1α Signaling
por: Li, Xiaolin, et al.
Publicado: (2022)

HIF pathway and c-Myc as biomarkers for response to sunitinib in metastatic clear-cell renal cell carcinoma
por: Maroto, P, et al.
Publicado: (2017)

Regulation of Osteoclast Growth and Fusion by mTOR/raptor and mTOR/rictor/Akt
por: Tiedemann, Kerstin, et al.
Publicado: (2017)

Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway
por: Yan, Xianke, et al.
Publicado: (2020)

Metformin represses the pathophysiology of AAA by suppressing the activation of PI3K/AKT/mTOR/autophagy pathway in ApoE(−/−) mice
por: Wang, Zhu, et al.
Publicado: (2019)

Demethylation of HIN-1 reverses paclitaxel-resistance of ovarian clear cell carcinoma through the AKT-mTOR signaling pathway
por: Ho, Chih-Ming, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_7u66c1tp6hb9k1ds57rpar336t