SLC6A8-mediated intracellular creatine accumulation enhances hypoxic breast cancer cell survival via ameliorating oxidative stress

BACKGROUND: Triple-negative breast cancer (TNBC) is the most aggressive subtype of breast cancer, with poor prognosis and limited treatment options. Hypoxia is a key hallmark of TNBC. Metabolic adaptation promotes progression of TNBC cells that are located within the hypoxic tumor regions. However,...

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Detalles Bibliográficos
Autores principales: Li, Qiao, Liu, Manran, Sun, Yan, Jin, Ting, Zhu, Pengpeng, Wan, Xueying, Hou, Yixuan, Tu, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120850/
https://www.ncbi.nlm.nih.gov/pubmed/33990217
http://dx.doi.org/10.1186/s13046-021-01933-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8120850/
https://www.ncbi.nlm.nih.gov/pubmed/33990217
http://dx.doi.org/10.1186/s13046-021-01933-7

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