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Ultra-High Dose Rate FLASH Irradiation Induced Radio-Resistance of Normal Fibroblast Cells Can Be Enhanced by Hypoxia and Mitochondrial Dysfunction Resulting From Loss of Cytochrome C

Ultra-high dose rate FLASH irradiation (FLASH-IR) has got extensive attention since it may provide better protection on normal tissues while maintain tumor killing effect compared with conventional dose rate irradiation. The FLASH-IR induced protection effect on normal tissues is exhibited as radio-...

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Detalles Bibliográficos
Autores principales: Han, Jintao, Mei, Zhusong, Lu, Chunyang, Qian, Jing, Liang, Yulan, Sun, Xiaoyi, Pan, Zhuo, Kong, Defeng, Xu, Shirui, Liu, Zhipeng, Gao, Ying, Qi, Guijun, Shou, Yinren, Chen, Shiyou, Cao, Zhengxuan, Zhao, Ye, Lin, Chen, Zhao, Yanying, Geng, Yixing, Chen, Jiaer, Yan, Xueqing, Ma, Wenjun, Yang, Gen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121317/
https://www.ncbi.nlm.nih.gov/pubmed/33996831
http://dx.doi.org/10.3389/fcell.2021.672929