Cargando…

The cGAS-STING pathway: The role of self-DNA sensing in inflammatory lung disease

The presence of DNA in the cytosol is usually a sign of microbial infections, which alerts the host innate immune system to mount a defense response. Cyclic GMP-AMP synthase (cGAS) is a critical cytosolic DNA sensor that elicits robust innate immune responses through the production of the second mes...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Ruihua, Ortiz Serrano, Tatiana P., Davis, Jennifer, Prigge, Andrew D., Ridge, Karen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121456/ https://www.ncbi.nlm.nih.gov/pubmed/32860267 http://dx.doi.org/10.1096/fj.202001607R

Ejemplares similares

Self-DNA Sensing by cGAS-STING and TLR9 in Autoimmunity: Is the Cytoskeleton in Control?
por: Amadio, Roberto, et al.
Publicado: (2021)

cGAS and STING: At the intersection of DNA and RNA virus-sensing networks
por: Ni, Guoxin, et al.
Publicado: (2018)

The Cytosolic DNA-Sensing cGAS-STING Pathway in Liver Diseases
por: Wang, Zhilei, et al.
Publicado: (2021)

Beyond DNA sensing: expanding the role of cGAS/STING in immunity and diseases
por: Seok, Jin Kyung, et al.
Publicado: (2023)

Cytosolic DNA sensing through cGAS and STING is inactivated by gene mutations in pangolins
por: Fischer, Heinz, et al.
Publicado: (2020)

How the Innate Immune DNA Sensing cGAS–STING Pathway Is Involved in Autophagy
por: Zheng, Wanglong, et al.
Publicado: (2021)

How the Innate Immune DNA Sensing cGAS-STING Pathway Is Involved in Apoptosis
por: Zheng, Wanglong, et al.
Publicado: (2023)

Intervention of cGAS‒STING signaling in sterile inflammatory diseases
por: Hong, Ze, et al.
Publicado: (2022)

IFI16 and cGAS cooperate in the activation of STING during DNA sensing in human keratinocytes
por: Almine, Jessica F., et al.
Publicado: (2017)

DNA sensing via the cGAS/STING pathway activates the immunoproteasome and adaptive T‐cell immunity
por: Wang, Xinyuan, et al.
Publicado: (2023)

DNA sensing in cancer: Pro-tumour and anti-tumour functions of cGAS–STING signalling
por: Wheeler, Otto P.G., et al.
Publicado: (2023)

The cGAS-STING pathway-dependent sensing of mitochondrial DNA mediates ocular surface inflammation
por: Ouyang, Weijie, et al.
Publicado: (2023)

cGAS-independent STING activation in response to DNA damage
por: Unterholzner, Leonie, et al.
Publicado: (2019)

cGAS-STING Pathway as the Target of Immunotherapy for Lung Cancer
por: Dan, Qinfu, et al.
Publicado: (2023)

The cGAS Paradox: Contrasting Roles for cGAS-STING Pathway in Chromosomal Instability
por: Hong, Christy, et al.
Publicado: (2019)

cGAS-STING pathway in cancer biotherapy
por: Wang, Yang, et al.
Publicado: (2020)

The cGAS–STING pathway as a therapeutic target in inflammatory diseases
por: Decout, Alexiane, et al.
Publicado: (2021)

Chicken DNA Sensing cGAS-STING Signal Pathway Mediates Broad Spectrum Antiviral Functions
por: Li, Shuangjie, et al.
Publicado: (2020)

Hepatitis B Virus DNA is a Substrate for the cGAS/STING Pathway but is not Sensed in Infected Hepatocytes
por: Lauterbach-Rivière, Lise, et al.
Publicado: (2020)

Avian oncogenic herpesvirus antagonizes the cGAS-STING DNA-sensing pathway to mediate immune evasion
por: Li, Kai, et al.
Publicado: (2019)

The Innate Immune DNA Sensing cGAS-STING Signaling Pathway Mediates Anti-PRRSV Function
por: Xu, Yulin, et al.
Publicado: (2021)

NETs Promote Inflammatory Injury by Activating cGAS-STING Pathway in Acute Lung Injury
por: Zhao, Jie, et al.
Publicado: (2023)

cGAS–STING cytosolic DNA sensing pathway is suppressed by JAK2-STAT3 in tumor cells
por: Suter, Manuel Adrian, et al.
Publicado: (2021)

A Bibliometric Analysis of the Innate Immune DNA Sensing cGAS-STING Pathway from 2013 to 2021
por: Shi, Xuan, et al.
Publicado: (2022)

cGAS-STING pathway in oncogenesis and cancer therapeutics
por: Hoong, Brandon Yi Da, et al.
Publicado: (2020)

Attenuation of cGAS/STING activity during mitosis
por: Uhlorn, Brittany L, et al.
Publicado: (2020)

The interactions between cGAS-STING pathway and pathogens
por: Cheng, Zhangliang, et al.
Publicado: (2020)

cGAS-STING, an important pathway in cancer immunotherapy
por: Jiang, Minlin, et al.
Publicado: (2020)

The Complexity of the cGAS-STING Pathway in CNS Pathologies
por: Fryer, Amelia L., et al.
Publicado: (2021)

The role of cGAS-STING signalling in liver diseases
por: Chen, Ruihan, et al.
Publicado: (2021)

cGAS/STING: novel perspectives of the classic pathway
por: Gao, Menghui, et al.
Publicado: (2020)

Advances in cGAS-STING Signaling Pathway and Diseases
por: Yang, Yuting, et al.
Publicado: (2022)

Mitotic inactivation of the cGAS‒MITA/STING pathways
por: Zhong, Li, et al.
Publicado: (2021)

Telomere Maintenance and the cGAS-STING Pathway in Cancer
por: Ebata, Hiroshi, et al.
Publicado: (2022)

Intercellular transmission of cGAS-STING signaling in cancer
por: Wu, Qirou, et al.
Publicado: (2023)

Role of cGAS–Sting Signaling in Alzheimer’s Disease
por: Govindarajulu, Manoj, et al.
Publicado: (2023)

The Activation of cGAS-STING in Acute Kidney Injury
por: Sun, Chuanchuan, et al.
Publicado: (2023)

Targeting the loss of cGAS/STING signaling in cancer
por: Sasaki, Nobunari, et al.
Publicado: (2023)

Significance of the cGAS-STING Pathway in Health and Disease
por: Zhou, Jinglin, et al.
Publicado: (2023)

cGAS-STING triggers inflammaging-associated neurodegeneration
por: Izquierdo, José M.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_v8e712ell8nft8q94bpj1bu6l5