miR-204 silencing reduces mitochondrial autophagy and ROS production in a murine AD model via the TRPML1-activated STAT3 pathway

Mitochondrial dysfunction is an early feature of Alzheimer’s disease (AD), whereby accumulation of damaged mitochondria in conjunction with impaired mitophagy contributes to neurodegeneration. Various non-transcribed microRNAs (miRNAs) are involved in this process. In the present study, we aimed to...

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Detalles Bibliográficos
Autores principales: Zhang, Lu, Fang, Yu, Zhao, Xinyu, Zheng, Yake, Ma, Yunqing, Li, Shuang, Huang, Zhi, Li, Lihao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2021
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121631/
https://www.ncbi.nlm.nih.gov/pubmed/34026326
http://dx.doi.org/10.1016/j.omtn.2021.02.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121631/
https://www.ncbi.nlm.nih.gov/pubmed/34026326
http://dx.doi.org/10.1016/j.omtn.2021.02.010

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