Cargando…
Enzymatic bypass and the structural basis of miscoding opposite the DNA adduct 1,N(2)-ethenodeoxyguanosine by human DNA translesion polymerase η
Etheno (ε)-adducts, e.g., 1,N(2)-ε−guanine (1,N(2)-ε-G) and 1,N(6)-ε−adenine (1,N(6)-ε-A), are formed through the reaction of DNA with metabolites of vinyl compounds or with lipid peroxidation products. These lesions are known to be mutagenic, but it is unknown how they lead to errors in DNA replica...
| Autores principales: | , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121704/ https://www.ncbi.nlm.nih.gov/pubmed/33839151 http://dx.doi.org/10.1016/j.jbc.2021.100642 |