Non-quaternary oximes detoxify nerve agents and reactivate nerve agent-inhibited human butyrylcholinesterase

Government-sanctioned use of nerve agents (NA) has escalated dramatically in recent years. Oxime reactivators of organophosphate (OP)-inhibited acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) serve as antidotes toward poisoning by OPNAs. The oximes used as therapeutics are quaternary co...

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Detalles Bibliográficos
Autores principales: Amitai, Gabriel, Plotnikov, Alexander, Chapman, Shira, Lazar, Shlomi, Gez, Rellie, Loewenthal, Dan, Shurrush, Khriesto A., Cohen, Galit, Solmesky, Leonardo J., Barr, Haim, Russell, Alan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121814/
https://www.ncbi.nlm.nih.gov/pubmed/33990679
http://dx.doi.org/10.1038/s42003-021-02061-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121814/
https://www.ncbi.nlm.nih.gov/pubmed/33990679
http://dx.doi.org/10.1038/s42003-021-02061-w

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