Comparison of gene expression and biotransformation activity of HepaRG cells under static and dynamic culture conditions

Flow conditions have been shown to be important in improving longevity and functionality of primary hepatocytes, but the impact of flow on HepaRG cells is largely unknown. We studied the expression of genes encoding CYP enzymes and transporter proteins and CYP1 and CYP3A4 activity during 8 weeks of...

Descripción completa

Detalles Bibliográficos
Autores principales: Duivenvoorde, Loes P. M., Louisse, Jochem, Pinckaers, Nicole E. T., Nguyen, Tien, van der Zande, Meike
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121841/
https://www.ncbi.nlm.nih.gov/pubmed/33990636
http://dx.doi.org/10.1038/s41598-021-89710-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121841/
https://www.ncbi.nlm.nih.gov/pubmed/33990636
http://dx.doi.org/10.1038/s41598-021-89710-6

Ejemplares similares