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Comparison of gene expression and biotransformation activity of HepaRG cells under static and dynamic culture conditions
Flow conditions have been shown to be important in improving longevity and functionality of primary hepatocytes, but the impact of flow on HepaRG cells is largely unknown. We studied the expression of genes encoding CYP enzymes and transporter proteins and CYP1 and CYP3A4 activity during 8 weeks of...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121841/ https://www.ncbi.nlm.nih.gov/pubmed/33990636 http://dx.doi.org/10.1038/s41598-021-89710-6 |