Oxygen tension modulates the mitochondrial genetic bottleneck and influences the segregation of a heteroplasmic mtDNA variant in vitro

Most humans carry a mixed population of mitochondrial DNA (mtDNA heteroplasmy) affecting ~1–2% of molecules, but rapid percentage shifts occur over one generation leading to severe mitochondrial diseases. A decrease in the amount of mtDNA within the developing female germ line appears to play a role...

Descripción completa

Detalles Bibliográficos
Autores principales: Pezet, Mikael G., Gomez-Duran, Aurora, Klimm, Florian, Aryaman, Juvid, Burr, Stephen, Wei, Wei, Saitou, Mitinori, Prudent, Julien, Chinnery, Patrick F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121860/
https://www.ncbi.nlm.nih.gov/pubmed/33990696
http://dx.doi.org/10.1038/s42003-021-02069-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121860/
https://www.ncbi.nlm.nih.gov/pubmed/33990696
http://dx.doi.org/10.1038/s42003-021-02069-2

Ejemplares similares