Tissue context determines the penetrance of regulatory DNA variation

Functional assessment of disease-associated sequence variation at non-coding regulatory elements is complicated by their high degree of context sensitivity to both the local chromatin and nuclear environments. Allelic profiling of DNA accessibility across individuals has shown that only a select min...

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Detalles Bibliográficos
Autores principales: Halow, Jessica M., Byron, Rachel, Hogan, Megan S., Ordoñez, Raquel, Groudine, Mark, Bender, M. A., Stamatoyannopoulos, John A., Maurano, Matthew T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121920/
https://www.ncbi.nlm.nih.gov/pubmed/33990600
http://dx.doi.org/10.1038/s41467-021-23139-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121920/
https://www.ncbi.nlm.nih.gov/pubmed/33990600
http://dx.doi.org/10.1038/s41467-021-23139-3

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