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Molecular mechanisms of ion conduction and ion selectivity in TMEM16 lipid scramblases

TMEM16 lipid scramblases transport lipids and also operate as ion channels with highly variable ion selectivities and various physiological functions. However, their molecular mechanisms of ion conduction and selectivity remain largely unknown. Using computational electrophysiology simulations at at...

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Detalles Bibliográficos
Autores principales: Kostritskii, Andrei Y., Machtens, Jan-Philipp
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8121942/
https://www.ncbi.nlm.nih.gov/pubmed/33990555
http://dx.doi.org/10.1038/s41467-021-22724-w