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Defining intermediates and redundancies in coenzyme Q precursor biosynthesis
Coenzyme Q (CoQ), a redox-active lipid essential for oxidative phosphorylation, is synthesized by virtually all cells, but how eukaryotes make the universal CoQ head group precursor 4-hydroxybenzoate (4-HB) from tyrosine is unknown. The first and last steps of this pathway have been defined in Sacch...
Autores principales: | Robinson, Kyle P., Jochem, Adam, Johnson, Sheila E., Reddy, Thiruchelvi R., Russell, Jason D., Coon, Joshua J., Pagliarini, David J. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122105/ https://www.ncbi.nlm.nih.gov/pubmed/33862086 http://dx.doi.org/10.1016/j.jbc.2021.100643 |
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