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Production of single- and multiple-gene-modified mice via maternal SpCas9-based gene editing
Maternally and transiently accumulated SpCas9 (maternal SpCas9) in a zygote derived from a systemically SpCas9-expressing transgenic mouse strain was used to generate single- and multiple-gene-modified mice. Maternal SpCas9-based gene editing allows for high indel and knockin mutation efficiency, lo...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2021
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122177/ https://www.ncbi.nlm.nih.gov/pubmed/34027476 http://dx.doi.org/10.1016/j.xpro.2021.100509 |