Cargando…

Mitochondrial ATP-Dependent Proteases—Biological Function and Potential Anti-Cancer Targets

SIMPLE SUMMARY: Alterations of cellular metabolism and bioenergetics, oxidative stress, and intracellular reactive oxygen species (ROS) levels are hallmarks of cancer development. Mitochondrial proteases, especially ATP-dependent proteases are essential to regulate mitochondrial function by maintain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Feng, Yue, Nouri, Kazem, Schimmer, Aaron D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122244/ https://www.ncbi.nlm.nih.gov/pubmed/33922062 http://dx.doi.org/10.3390/cancers13092020

Ejemplares similares

Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy
por: Nouri, Kazem, et al.
Publicado: (2020)

The role of mitochondrial proteases in leukemic cells and leukemic stem cells
por: Mirali, Sara, et al.
Publicado: (2020)

Alpha-synuclein suppresses mitochondrial protease ClpP to trigger mitochondrial oxidative damage and neurotoxicity
por: Hu, Di, et al.
Publicado: (2019)

Characterization of the ATP-Dependent Lon-Like Protease in Methanobrevibacter smithii
por: Pei, Jihua, et al.
Publicado: (2016)

Evidence That Two ATP-Dependent (Lon) Proteases in Borrelia burgdorferi Serve Different Functions
por: Coleman, James L., et al.
Publicado: (2009)

Role of the Inserted α-Helical Domain in E. coli ATP-Dependent Lon Protease Function
por: Kudzhaev, A. M., et al.
Publicado: (2017)

Structural studies on Helicobacter pylori ATP-dependent protease, FtsH
por: Kim, Sung Hyun, et al.
Publicado: (2008)

PrkA is an ATP-dependent protease that regulates sporulation in Bacillus subtilis
por: Zhang, Ao, et al.
Publicado: (2022)

Cleavage-Dependent Activation of ATP-Dependent Protease HslUV from Staphylococcus aureus
por: Jeong, Soyeon, et al.
Publicado: (2020)

The mitochondrial ATP synthase as an ATP consumer—a surprising therapeutic target
por: Valdebenito, Gabriel E, et al.
Publicado: (2023)

ATP-Dependent Lon Protease Contributes to Helicobacter pylori-Induced Gastric Carcinogenesis
por: Luo, Bin, et al.
Publicado: (2016)

Mitochondrial ATP synthase: architecture, function and pathology
por: Jonckheere, An I., et al.
Publicado: (2011)

In Vivo Function of Hsp90 Is Dependent on ATP Binding and ATP Hydrolysis
por: Obermann, Wolfgang M.J., et al.
Publicado: (1998)

Alternative topogenesis of Mgm1 and mitochondrial morphology depend on ATP and a functional import motor
por: Herlan, Mark, et al.
Publicado: (2004)

Mitochondrial‐derived vesicles retain membrane potential and contain a functional ATP synthase
por: Hazan (Ben‐Menachem), Reut, et al.
Publicado: (2023)

Aep3p-dependent translation of yeast mitochondrial ATP8
por: Barros, Mario H., et al.
Publicado: (2017)

Understanding structure, function, and mutations in the mitochondrial ATP synthase
por: Xu, Ting, et al.
Publicado: (2015)

Inhibition of mitochondrial LonP1 protease by allosteric blockade of ATP binding and hydrolysis via CDDO and its derivatives
por: Lee, Jae, et al.
Publicado: (2022)

AAA Proteases: Guardians of Mitochondrial Function and Homeostasis
por: Opalińska, Magdalena, et al.
Publicado: (2018)

Targeting breast cancer metabolism with a novel inhibitor of mitochondrial ATP synthesis
por: Kim, Myoung Sook, et al.
Publicado: (2020)

The Mitochondrial ATP Synthase/IF1 Axis in Cancer Progression: Targets for Therapeutic Intervention
por: Domínguez-Zorita, Sonia, et al.
Publicado: (2023)

SENP Proteases as Potential Targets for Cancer Therapy
por: Tokarz, Paulina, et al.
Publicado: (2021)

A Lon-Like Protease with No ATP-Powered Unfolding Activity
por: Liao, Jiahn-Haur, et al.
Publicado: (2012)

Targeting cancer stem cells expressing an embryonic signature with anti-proteases to decrease their tumor potential
por: Darini, C Y, et al.
Publicado: (2013)

Mitochondrial protein sorting as a therapeutic target for ATP synthase disorders
por: Aiyar, Raeka S., et al.
Publicado: (2014)

The mitochondrial ATP synthase is a shared drug target for aging and dementia
por: Goldberg, Joshua, et al.
Publicado: (2018)

Mitochondrial ATP Synthase is a Target of Oxidative Stress in Neurodegenerative Diseases
por: Ebanks, Brad, et al.
Publicado: (2022)

H(+) Transport is an Integral Function of the Mitochondrial ADP/ATP Carrier
por: Bertholet, Ambre M., et al.
Publicado: (2019)

The mitochondrial ADP/ATP carrier exists and functions as a monomer
por: Kunji, Edmund R.S., et al.
Publicado: (2020)

Protection against Mitochondrial and Metal Toxicity Depends on Functional Lipid Binding Sites in ATP13A2
por: Martin, Shaun, et al.
Publicado: (2016)

Induction of Posttranslational Modifications of Mitochondrial Proteins by ATP Contributes to Negative Regulation of Mitochondrial Function
por: Zhang, Yong, et al.
Publicado: (2016)

The Role of Mitochondrial H(+)-ATP Synthase in Cancer
por: Esparza-Moltó, Pau B., et al.
Publicado: (2018)

Novel mitochondrial mutations in the ATP6 and ATP8 genes in patients with breast cancer
por: GRZYBOWSKA-SZATKOWSKA, LUDMIŁA, et al.
Publicado: (2014)

Mitochondrial cereblon functions as a Lon-type protease
por: Kataoka, Kosuke, et al.
Publicado: (2016)

Mitochondrial flashes regulate ATP homeostasis in the heart
por: Wang, Xianhua, et al.
Publicado: (2017)

Bedaquiline, an FDA-approved drug, inhibits mitochondrial ATP production and metastasis in vivo, by targeting the gamma subunit (ATP5F1C) of the ATP synthase
por: Fiorillo, Marco, et al.
Publicado: (2021)

Functional protection against cardiac diseases depends on ATP‐sensitive potassium channels
por: Ye, Peng, et al.
Publicado: (2018)

Mechanisms and Functions of ATP-Dependent Chromatin-Remodeling Enzymes
por: Narlikar, Geeta J., et al.
Publicado: (2013)

ATP translocation and chloroplast biology
por: Voon, Chia P, et al.
Publicado: (2019)

Targeting nuclear import and export in hematological malignancies
por: Nachmias, Boaz, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_esosm248i2m1cvnl1mqgm44c87