Oxaliplatin-Induced Senescence in Colorectal Cancer Cells Depends on p14(ARF)-Mediated Sustained p53 Activation

SIMPLE SUMMARY: Chemotherapy can lead to cellular senescence in tumor cells. Here we demonstrate that oxaliplatin induces senescence in p53-proficient colorectal cancer (CRC) cells and leads to the G2-phase arrest in all lines studied (HCT116(p53+/+,) HCT116(p53−/−), LoVo, SW48, and SW480). At early...

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Detalles Bibliográficos
Autores principales: Tomicic, Maja T., Krämer, Franziska, Nguyen, Alexandra, Schwarzenbach, Christian, Christmann, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122251/
https://www.ncbi.nlm.nih.gov/pubmed/33922007
http://dx.doi.org/10.3390/cancers13092019

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122251/
https://www.ncbi.nlm.nih.gov/pubmed/33922007
http://dx.doi.org/10.3390/cancers13092019

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