Impaired 26S Proteasome Assembly Precedes Neuronal Loss in Mutant UBQLN2 Rats

Proteasomal dysfunction is known to be associated with amyotrophic lateral sclerosis and frontotemporal degeneration (ALS/FTD). Our previous reports have shown that a mutant form of ubiquilin-2 (UBQLN2) linked to ALS/FTD leads to neurodegeneration accompanied by accumulations of the proteasome subun...

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Detalles Bibliográficos
Autores principales: Zhang, Wenjuan, Huang, Bo, Gao, Limo, Huang, Cao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122323/
https://www.ncbi.nlm.nih.gov/pubmed/33919255
http://dx.doi.org/10.3390/ijms22094319

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122323/
https://www.ncbi.nlm.nih.gov/pubmed/33919255
http://dx.doi.org/10.3390/ijms22094319

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