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Reconciling the Biological and Transcriptional Variability of Hepatoblastoma with Its Mutational Uniformity

SIMPLE SUMMARY: Hepatoblastoma (HB), the most common form of childhood liver cancer, is associated with dual mutation and/or dysregulation of the Wnt/β-catenin and Hippo pathways in ~50% of cases. However, this mutational simplicity cannot explain HB’s biological and histologic diversity. This discu...

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Detalles Bibliográficos
Autor principal: Prochownik, Edward V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122429/
https://www.ncbi.nlm.nih.gov/pubmed/33919162
http://dx.doi.org/10.3390/cancers13091996