Coumarin-Chalcone Hybrids as Inhibitors of MAO-B: Biological Activity and In Silico Studies

Fourteen coumarin-derived compounds modified at the C3 carbon of coumarin with an α,β-unsaturated ketone were synthesized. These compounds may be designated as chalcocoumarins (3-cinnamoyl-2H-chromen-2-ones). Both chalcones and coumarins are recognized scaffolds in medicinal chemistry, showing diver...

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Detalles Bibliográficos
Autores principales: Moya-Alvarado, Guillermo, Yañez, Osvaldo, Morales, Nicole, González-González, Angélica, Areche, Carlos, Núñez, Marco Tulio, Fierro, Angélica, García-Beltrán, Olimpo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122463/
https://www.ncbi.nlm.nih.gov/pubmed/33921982
http://dx.doi.org/10.3390/molecules26092430

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122463/
https://www.ncbi.nlm.nih.gov/pubmed/33921982
http://dx.doi.org/10.3390/molecules26092430

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