Cargando…

New Succinimides with Potent Anticancer Activity: Synthesis, Activation of Stress Signaling Pathways and Characterization of Apoptosis in Leukemia and Cervical Cancer Cells

Based on previously identified dicarboximides with significant anticancer and immunomodulatory activities, a series of 26 new derivatives were designed and synthesized by the Diels–Alder reaction between appropriate diene and maleimide or hydroxymaleimide moieties. The resulting imides were function...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cieślak, Marcin, Napiórkowska, Mariola, Kaźmierczak-Barańska, Julia, Królewska-Golińska, Karolina, Hawrył, Anna, Wybrańska, Iwona, Nawrot, Barbara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122671/ https://www.ncbi.nlm.nih.gov/pubmed/33919224 http://dx.doi.org/10.3390/ijms22094318

Ejemplares similares

Synthesis of New Derivatives of Benzofuran as Potential Anticancer Agents
por: Napiórkowska, Mariola, et al.
Publicado: (2019)

New Thalidomide-Resembling Dicarboximides Target ABC50 Protein and Show Antileukemic and Immunomodulatory Activities
por: Cieślak, Marcin, et al.
Publicado: (2019)

Novel Dicarboximide BK124.1 Breaks Multidrug Resistance and Shows Anticancer Efficacy in Chronic Myeloid Leukemia Preclinical Models and Patients’ CD34(+)/CD38(−) Leukemia Stem Cells
por: Stukan, Iga, et al.
Publicado: (2022)

Diselenides and Benzisoselenazolones as Antiproliferative Agents and Glutathione-S-Transferase Inhibitors
por: Krasowska, Dorota, et al.
Publicado: (2019)

High Cytotoxic Activity of Phosphonium Salts and Their Complementary Selectivity towards HeLa and K562 Cancer Cells: Identification of Tri-n-butyl-n-hexadecylphosphonium bromide as a Highly Potent Anti-HeLa Phosphonium Salt
por: Bachowska, Barbara, et al.
Publicado: (2012)

Succinimid of Mercury
por: Wright, B. L.
Publicado: (1916)

Synthesis, Antioxidant, and Antidiabetic Activities of Ketone Derivatives of Succinimide
por: Waheed, Bushra, et al.
Publicado: (2022)

Biological Evaluation of 3-Benzylidenechromanones and Their Spiropyrazolines-Based Analogues
por: Adamus-Grabicka, Angelika A., et al.
Publicado: (2020)

Kinetic Studies of Newly Patented Aminoalkanol Derivatives with Potential Anticancer Activity as Competitive Inhibitors of Prostate Acid Phosphatase
por: Grodner, Błażej, et al.
Publicado: (2021)

Facts Regarding Succinimide of Mercury
por: Reed, Geo. H.
Publicado: (1916)

Dual 2-Hydroxypropyl-β-Cyclodextrin and 5,10,15,20-Tetrakis (4-Hydroxyphenyl) Porphyrin System as a Novel Chiral-Achiral Selector Complex for Enantioseparation of Aminoalkanol Derivatives with Anticancer Activity in Capillary Electrophoresis
por: Grodner, Błażej, et al.
Publicado: (2021)

Comparative Cholinesterase, α-Glucosidase Inhibitory, Antioxidant, Molecular Docking, and Kinetic Studies on Potent Succinimide Derivatives
por: Ahmad, Ashfaq, et al.
Publicado: (2020)

Selenium-Containing Exopolysaccharides Isolated from the Culture Medium of Lentinula edodes: Structure and Biological Activity
por: Górska-Jakubowska, Sandra, et al.
Publicado: (2021)

N-(3-Chlorophenyl)succinimide
por: Saraswathi, B. S., et al.
Publicado: (2011)

N-(3-Methylphenyl)succinimide
por: Saraswathi, B. S., et al.
Publicado: (2010)

N-(4-Methylphenyl)succinimide
por: Saraswathi, B. S., et al.
Publicado: (2010)

N-(2-Chlorophenyl)succinimide
por: Saraswathi, B. S., et al.
Publicado: (2010)

Vitamin B12—Multifaceted In Vivo Functions and In Vitro Applications
por: Halczuk, Krzysztof, et al.
Publicado: (2023)

N-(2,4-Dimethylphenyl)succinimide
por: Saraswathi, B. S., et al.
Publicado: (2010)

N-(2,3-Dimethylphenyl)succinimide
por: Saraswathi, B. S., et al.
Publicado: (2010)

N-(2,6-Dimethylphenyl)succinimide
por: Saraswathi, B. S., et al.
Publicado: (2010)

Mental Health and the Symptoms of PTSD in People with Depression and Anxiety Disorders during the COVID-19 Pandemic
por: Golińska, Paulina Beata, et al.
Publicado: (2021)

Mentalization and Its Relation to Life Satisfaction and the Level of Mental Adjustment to Illness in Women with Breast Cancer—A Pilot Study
por: Cieślak, Mariusz, et al.
Publicado: (2022)

An Electrochemical DNA Microbiosensor Based on Succinimide-Modified Acrylic Microspheres
por: Ulianas, Alizar, et al.
Publicado: (2012)

Crystal structure of N-(3-hydroxyphenyl)succinimide
por: Suchetan, P. A., et al.
Publicado: (2014)

The Potent Oxidant Anticancer Activity of Organoiridium Catalysts**
por: Liu, Zhe, et al.
Publicado: (2014)

Liquid chromatography fingerprint analysis and antioxidant activity of selected lavender species with chemometric calculations
por: Hawrył, Anna, et al.
Publicado: (2019)

The Influence of 5′R and 5′S cdA and cdG on the Activity of BsmAI and SspI Restriction Enzymes
por: Szewczuk, Michał, et al.
Publicado: (2021)

Biocidal Polymers: Synthesis, Characterization and Antimicrobial Activity of Bis-Quaternary Onium Salts of Poly(aspartate-co-succinimide)
por: El-Newehy, Mohamed H., et al.
Publicado: (2020)

On-Demand Detachment of Succinimides on Cysteine to Facilitate (Semi)Synthesis of Challenging Proteins
por: Vamisetti, Ganga B., et al.
Publicado: (2020)

Cover Feature: Organometallic Nucleosides: Synthesis and Biological Evaluation of Substituted Dicobalt Hexacarbonyl 2′‐Deoxy‐5‐oxopropynyluridines (ChemistryOpen 3/2018)
por: Kaczmarek, Renata, et al.
Publicado: (2018)

Organometallic Nucleosides: Synthesis and Biological Evaluation of Substituted Dicobalt Hexacarbonyl 2′‐Deoxy‐5‐oxopropynyluridines
por: Kaczmarek, Renata, et al.
Publicado: (2018)

When UDG and hAPE1 Meet Cyclopurines. How (5′R) and (5′S) 5′,8-Cyclo-2′-deoxyadenosine and 5′,8-Cyclo-2′-deoxyguanosine Affect UDG and hAPE1 Activity?
por: Szewczuk, Michał, et al.
Publicado: (2021)

Discovery of Potent and Selective Halogen-Substituted Imidazole-Thiosemicarbazides for Inhibition of Toxoplasma gondii Growth In Vitro via Structure-Based Design
por: Paneth, Agata, et al.
Publicado: (2019)

NHC-Catalyzed Asymmetric Synthesis of Functionalized Succinimides from Enals and α-Ketoamides
por: Wang, Lei, et al.
Publicado: (2015)

Stereodivergent synthesis of chiral succinimides via Rh-catalyzed asymmetric transfer hydrogenation
por: Wang, Fangyuan, et al.
Publicado: (2022)

Identification of an irreversible PPARγ antagonist with potent anticancer activity
por: Peng, Youyi, et al.
Publicado: (2020)

Cyclooxygenase-Inhibiting Platinum(IV) Prodrugs with Potent Anticancer Activity
por: Khoury, Aleen, et al.
Publicado: (2022)

Catalase Inhibition by Aminoalkanol Derivatives with Potential Anti-Cancer Activity—In Vitro and In Silico Studies Using Capillary Electrophoresis Method
por: Grodner, Błażej, et al.
Publicado: (2022)

Rhaponticum carthamoides Transformed Root Extract Has Potent Anticancer Activity in Human Leukemia and Lung Adenocarcinoma Cell Lines
por: Skała, Ewa, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_a6de3dmqr744t6lvjppgb817gj