Allosteric Modulation of the CB1 Cannabinoid Receptor by Cannabidiol—A Molecular Modeling Study of the N-Terminal Domain and the Allosteric-Orthosteric Coupling

The CB(1) cannabinoid receptor (CB(1)R) contains one of the longest N termini among class A G protein-coupled receptors. Mutagenesis studies suggest that the allosteric binding site of cannabidiol (CBD) involves residues from the N terminal domain. In order to study the allosteric binding of CBD to...

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Detalles Bibliográficos
Autores principales: Jakowiecki, Jakub, Abel, Renata, Orzeł, Urszula, Pasznik, Paweł, Preissner, Robert, Filipek, Sławomir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122825/
https://www.ncbi.nlm.nih.gov/pubmed/33922473
http://dx.doi.org/10.3390/molecules26092456

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8122825/
https://www.ncbi.nlm.nih.gov/pubmed/33922473
http://dx.doi.org/10.3390/molecules26092456

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