Identification of Novel Inhibitors of Escherichia coli DNA Ligase (LigA)

Present in all organisms, DNA ligases catalyse the formation of a phosphodiester bond between a 3′ hydroxyl and a 5′ phosphate, a reaction that is essential for maintaining genome integrity during replication and repair. Eubacterial DNA ligases use NAD(+) as a cofactor and possess low sequence and s...

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Detalles Bibliográficos
Autores principales: Alomari, Arqam, Gowland, Robert, Southwood, Callum, Barrow, Jak, Bentley, Zoe, Calvin-Nelson, Jashel, Kaminski, Alice, LeFevre, Matthew, Callaghan, Anastasia J., Vincent, Helen A., Gowers, Darren M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123306/
https://www.ncbi.nlm.nih.gov/pubmed/33923034
http://dx.doi.org/10.3390/molecules26092508

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123306/
https://www.ncbi.nlm.nih.gov/pubmed/33923034
http://dx.doi.org/10.3390/molecules26092508

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