Cargando…
Identification of Novel Inhibitors of Escherichia coli DNA Ligase (LigA)
Present in all organisms, DNA ligases catalyse the formation of a phosphodiester bond between a 3′ hydroxyl and a 5′ phosphate, a reaction that is essential for maintaining genome integrity during replication and repair. Eubacterial DNA ligases use NAD(+) as a cofactor and possess low sequence and s...
| Autores principales: | , , , , , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123306/ https://www.ncbi.nlm.nih.gov/pubmed/33923034 http://dx.doi.org/10.3390/molecules26092508 |