Complex Mechanisms of Antimony Genotoxicity in Budding Yeast Involves Replication and Topoisomerase I-Associated DNA Lesions, Telomere Dysfunction and Inhibition of DNA Repair

Antimony is a toxic metalloid with poorly understood mechanisms of toxicity and uncertain carcinogenic properties. By using a combination of genetic, biochemical and DNA damage assays, we investigated the genotoxic potential of trivalent antimony in the model organism Saccharomyces cerevisiae. We fo...

Descripción completa

Detalles Bibliográficos
Autores principales: Litwin, Ireneusz, Mucha, Seweryn, Pilarczyk, Ewa, Wysocki, Robert, Maciaszczyk-Dziubinska, Ewa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123508/
https://www.ncbi.nlm.nih.gov/pubmed/33925940
http://dx.doi.org/10.3390/ijms22094510

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123508/
https://www.ncbi.nlm.nih.gov/pubmed/33925940
http://dx.doi.org/10.3390/ijms22094510

Ejemplares similares