Chemical Degradation of Androgen Receptor (AR) Using Bicalutamide Analog–Thalidomide PROTACs

A series of PROTACs (PROteolysis-TArgeting Chimeras) consisting of bicalutamide analogs and thalidomides were designed, synthesized, and biologically evaluated as novel androgen receptor (AR) degraders. In particular, we found that PROTAC compound 13b could successfully demonstrate a targeted degrad...

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Detalles Bibliográficos
Autores principales: Kim, Ga Yeong, Song, Chae Won, Yang, Yo-Sep, Lee, Na-Rae, Yoo, Hyung-Seok, Son, Seung Hwan, Lee, Soo Jin, Park, Jong Seon, Lee, Jong Kil, Inn, Kyung-Soo, Kim, Nam-Jung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123623/
https://www.ncbi.nlm.nih.gov/pubmed/33926033
http://dx.doi.org/10.3390/molecules26092525

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123623/
https://www.ncbi.nlm.nih.gov/pubmed/33926033
http://dx.doi.org/10.3390/molecules26092525

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