Small-Molecule Inhibitors of the RNA M6A Demethylases FTO Potently Support the Survival of Dopamine Neurons

The fat mass and obesity-associated protein (FTO), an RNA N(6)-methyladenosine (m(6)A) demethylase, is an important regulator of central nervous system development, neuronal signaling and disease. We present here the target-tailored development and biological characterization of small-molecule inhib...

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Detalles Bibliográficos
Autores principales: Selberg, Simona, Yu, Li-Ying, Bondarenko, Olesja, Kankuri, Esko, Seli, Neinar, Kovaleva, Vera, Herodes, Koit, Saarma, Mart, Karelson, Mati
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123663/
https://www.ncbi.nlm.nih.gov/pubmed/33926120
http://dx.doi.org/10.3390/ijms22094537

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123663/
https://www.ncbi.nlm.nih.gov/pubmed/33926120
http://dx.doi.org/10.3390/ijms22094537

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