Cargando…

Chromatin-Directed Proteomics Identifies ZNF84 as a p53-Independent Regulator of p21 in Genotoxic Stress Response

SIMPLE SUMMARY: Chemotherapy is a commonly applied anticancer treatment, however therapy-induced senescent growth arrest has been associated with aggressive disease recurrence. The p21 protein, encoded by CDKN1A, plays a vital role in the induction of senescence. Its transcriptional control by p53 i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Strzeszewska-Potyrała, Anna, Staniak, Karolina, Czarnecka-Herok, Joanna, Rafiee, Mahmoud-Reza, Herok, Marcin, Mosieniak, Grażyna, Krijgsveld, Jeroen, Sikora, Ewa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8123910/ https://www.ncbi.nlm.nih.gov/pubmed/33925586 http://dx.doi.org/10.3390/cancers13092115

Ejemplares similares

Therapy-Induced Senescent/Polyploid Cancer Cells Undergo Atypical Divisions Associated with Altered Expression of Meiosis, Spermatogenesis and EMT Genes
por: Czarnecka-Herok, Joanna, et al.
Publicado: (2022)

Improved Autophagic Flux in Escapers from Doxorubicin-Induced Senescence/Polyploidy of Breast Cancer Cells
por: Bojko, Agnieszka, et al.
Publicado: (2020)

Diversity of the Senescence Phenotype of Cancer Cells Treated with Chemotherapeutic Agents
por: Bojko, Agnieszka, et al.
Publicado: (2019)

Insight into the role of PIKK family members and NF-кB in DNAdamage-induced senescence and senescence-associated secretory phenotype of colon cancer cells
por: Strzeszewska, Anna, et al.
Publicado: (2018)

Polyploidy Formation in Doxorubicin-Treated Cancer Cells Can Favor Escape from Senescence()
por: Mosieniak, Grazyna, et al.
Publicado: (2015)

Expanding the Circuitry of Pluripotency by Selective Isolation of Chromatin-Associated Proteins
por: Rafiee, Mahmoud-Reza, et al.
Publicado: (2016)

Genetic 3′UTR variations and clinical factors significantly contribute to survival prediction and clinical response in breast cancer patients
por: Pamuła-Piłat, Jolanta, et al.
Publicado: (2020)

Preferential translation of p53 target genes
por: Hisaoka, Miharu, et al.
Publicado: (2022)

Molecular chaperones in the acquisition of cancer cell chemoresistance with mutated TP53 and MDM2 up-regulation
por: Tracz-Gaszewska, Zuzanna, et al.
Publicado: (2017)

Acquisition of p53 mutations in response to the non-genotoxic p53 activator Nutlin-3
por: Aziz, Moammir H., et al.
Publicado: (2011)

Potentially Bioaccessible Phenolics from Mung Bean and Adzuki Bean Sprouts Enriched with Probiotic—Antioxidant Properties and Effect on the Motility and Survival of AGS Human Gastric Carcinoma Cells
por: Świeca, Michał, et al.
Publicado: (2020)

Chemotherapy of HER2- and MDM2-Enriched Breast Cancer Subtypes Induces Homologous Recombination DNA Repair and Chemoresistance
por: Herok, Marcin, et al.
Publicado: (2021)

Transcription-independent and -dependent p53-mediated apoptosis in response to genotoxic and non-genotoxic stress
por: Ho, Cheng-Jung, et al.
Publicado: (2019)

ZNF185 is a p53 target gene following DNA damage
por: Smirnov, Artem, et al.
Publicado: (2018)

Chromatin dysregulation by mutant p53
por: Pfister, Neil T., et al.
Publicado: (2016)

The Role of p53 in Marijuana Smoke Condensates-induced Genotoxicity and Apoptosis
por: Kim, Ha Ryong, et al.
Publicado: (2012)

Resistance of bone marrow stroma to genotoxic preconditioning is determined by p53
por: Fedtsova, Natalia, et al.
Publicado: (2021)

ZNF498 promotes hepatocellular carcinogenesis by suppressing p53-mediated apoptosis and ferroptosis via the attenuation of p53 Ser46 phosphorylation
por: Zhang, Xiuyuan, et al.
Publicado: (2022)

Inhibition of NADPH Oxidases Activity by Diphenyleneiodonium Chloride as a Mechanism of Senescence Induction in Human Cancer Cells
por: Piszczatowska, Katarzyna, et al.
Publicado: (2020)

Fiji-Based Tool for Rapid and Unbiased Analysis of SA-β-Gal Activity in Cultured Cells
por: Krzystyniak, Adam, et al.
Publicado: (2023)

ZNF143 in Chromatin Looping and Gene Regulation
por: Ye, Bingyu, et al.
Publicado: (2020)

Open Days P0'84
Publicado: (1984)

ATM and MET kinases are synthetic lethal with non-genotoxic activation of p53
por: Sullivan, Kelly D., et al.
Publicado: (2012)

Structure and Assembly of the Nup84p Complex
por: Siniossoglou, Symeon, et al.
Publicado: (2000)

Methylation-regulated ZNF545 inhibits growth of the p53-mutant KYSE150 cell line by inducing p21 and Bax
por: Fan, Yu, et al.
Publicado: (2019)

Methylation-regulated ZNF545 inhibits growth of the p53-mutant KYSE150 cell line by inducing p21 and Bax
por: Fan, Yu, et al.
Publicado: (2021)

ZNF143 Suppresses Cell Apoptosis and Promotes Proliferation in Gastric Cancer via ROS/p53 Axis
por: Zhang, Yi, et al.
Publicado: (2020)

The zinc figure protein ZNF575 impairs colorectal cancer growth via promoting p53 transcription
por: AN, NING, et al.
Publicado: (2023)

Nanomaterial genotoxicity evaluation using the high-throughput p53-binding protein 1 (53BP1) assay
por: Fontaine, Maelle, et al.
Publicado: (2023)

Cross-talk between HIF and p53 as mediators of molecular responses to physiological and genotoxic stresses
por: Obacz, Joanna, et al.
Publicado: (2013)

TAp73 promotes cell survival upon genotoxic stress by inhibiting p53 activity
por: Chen, Dongshi, et al.
Publicado: (2014)

The Cross Talk Between p53 and mTOR Pathways in Response to Physiological and Genotoxic Stresses
por: Cui, Danrui, et al.
Publicado: (2021)

Nanoparticle encapsulation of non-genotoxic p53 activator Inauhzin-C for improved therapeutic efficacy
por: Bhattarai, Nimisha, et al.
Publicado: (2021)

Convergent evolution of a genotoxic stress response in a parasite-specific p53 homolog
por: Wendt, George R., et al.
Publicado: (2022)

Multifaceted behavior of a doubly reduced arylborane in B–H-bond activation and hydroboration catalysis
por: Prey, Sven E., et al.
Publicado: (2022)

ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53
por: Ghouzzi, Vincent El, et al.
Publicado: (2016)

ZIKA virus elicits P53 activation and genotoxic stress in human neural progenitors similar to mutations involved in severe forms of genetic microcephaly and p53
por: Ghouzzi, Vincent El, et al.
Publicado: (2017)

ZNF500 abolishes breast cancer proliferation and sensitizes chemotherapy by stabilizing P53 via competing with MDM2
por: Ma, Xiaowen, et al.
Publicado: (2023)

Formation of stress-specific p53 binding patterns is influenced by chromatin but not by modulation of p53 binding affinity to response elements(†)
por: Millau, Jean-François, et al.
Publicado: (2011)

Low Levels of p53 Protein and Chromatin Silencing of p53 Target Genes Repress Apoptosis in Drosophila Endocycling Cells
por: Zhang, Bingqing, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_fr93sq8ttplrj24abq3kic9ev2