Dysregulated G2 phase checkpoint recovery pathway reduces DNA repair efficiency and increases chromosomal instability in a wide range of tumours

Defective DNA repair is being demonstrated to be a useful target in cancer treatment. Currently, defective repair is identified by specific gene mutations, however defective repair is a common feature of cancers without these mutations. DNA damage triggers cell cycle checkpoints that are responsible...

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Detalles Bibliográficos
Autores principales: Fernando, Madushan, Duijf, Pascal H. G., Proctor, Martina, Stevenson, Alexander J., Ehmann, Anna, Vora, Shivam, Skalamera, Dubravka, Adams, Mark, Gabrielli, Brian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124070/
https://www.ncbi.nlm.nih.gov/pubmed/33993200
http://dx.doi.org/10.1038/s41389-021-00329-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124070/
https://www.ncbi.nlm.nih.gov/pubmed/33993200
http://dx.doi.org/10.1038/s41389-021-00329-8

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