ONC201 induces the unfolded protein response (UPR) in high‐ and low‐grade ovarian carcinoma cell lines and leads to cell death regardless of platinum sensitivity

OBJECTIVES: Treatment of both platinum resistant high grade (HG) and low‐grade (LG) ovarian cancer (OVCA) poses significant challenges as neither respond well to conventional chemotherapy leading to morbidity and mortality. Identification of novel agents that can overcome chemoresistance is therefor...

Descripción completa

Detalles Bibliográficos
Autores principales: Rumman, Marufa, Buck, Steven, Polin, Lisa, Dzinic, Sijana, Boerner, Julie, Winer, Ira S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124100/
https://www.ncbi.nlm.nih.gov/pubmed/33932119
http://dx.doi.org/10.1002/cam4.3858

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124100/
https://www.ncbi.nlm.nih.gov/pubmed/33932119
http://dx.doi.org/10.1002/cam4.3858

Ejemplares similares