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ONC201 induces the unfolded protein response (UPR) in high‐ and low‐grade ovarian carcinoma cell lines and leads to cell death regardless of platinum sensitivity
OBJECTIVES: Treatment of both platinum resistant high grade (HG) and low‐grade (LG) ovarian cancer (OVCA) poses significant challenges as neither respond well to conventional chemotherapy leading to morbidity and mortality. Identification of novel agents that can overcome chemoresistance is therefor...
Autores principales: | Rumman, Marufa, Buck, Steven, Polin, Lisa, Dzinic, Sijana, Boerner, Julie, Winer, Ira S. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124100/ https://www.ncbi.nlm.nih.gov/pubmed/33932119 http://dx.doi.org/10.1002/cam4.3858 |
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