Development of an Acid-Labile Ketal Linked Amphiphilic Block Copolymer Nanoparticles for pH-Triggered Release of Paclitaxel

Here, we report on the construction of biodegradable poly(ethylene oxide monomethyl ether) (MPEO)-b-poly(ε-caprolactone) (PCL) nanoparticles (NPs) having acid-labile (acyclic ketal group) linkage at the block junction. In the presence of acidic pH, the nanoassemblies were destabilized as a consequen...

Descripción completa

Detalles Bibliográficos
Autores principales: Petrova, Svetlana Lukáš, Jäger, Eliézer, Jäger, Alessandro, Höcherl, Anita, Konefał, Rafał, Zhigunov, Alexander, Pavlova, Ewa, Janoušková, Olga, Hrubý, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124141/
https://www.ncbi.nlm.nih.gov/pubmed/34062772
http://dx.doi.org/10.3390/polym13091465

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124141/
https://www.ncbi.nlm.nih.gov/pubmed/34062772
http://dx.doi.org/10.3390/polym13091465

Ejemplares similares