Suppression of PGC-1α Drives Metabolic Dysfunction in TGFβ2-Induced EMT of Retinal Pigment Epithelial Cells

PGC-1α, a key orchestrator of mitochondrial metabolism, plays a crucial role in governing the energetically demanding needs of retinal pigment epithelial cells (RPE). We previously showed that silencing PGC-1α induced RPE to undergo an epithelial-mesenchymal-transition (EMT). Here, we show that indu...

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Detalles Bibliográficos
Autores principales: Shu, Daisy Y., Butcher, Erik R., Saint-Geniez, Magali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124188/
https://www.ncbi.nlm.nih.gov/pubmed/33946753
http://dx.doi.org/10.3390/ijms22094701

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124188/
https://www.ncbi.nlm.nih.gov/pubmed/33946753
http://dx.doi.org/10.3390/ijms22094701

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