Cargando…

Suppression of PGC-1α Drives Metabolic Dysfunction in TGFβ2-Induced EMT of Retinal Pigment Epithelial Cells

PGC-1α, a key orchestrator of mitochondrial metabolism, plays a crucial role in governing the energetically demanding needs of retinal pigment epithelial cells (RPE). We previously showed that silencing PGC-1α induced RPE to undergo an epithelial-mesenchymal-transition (EMT). Here, we show that indu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Shu, Daisy Y., Butcher, Erik R., Saint-Geniez, Magali
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124188/ https://www.ncbi.nlm.nih.gov/pubmed/33946753 http://dx.doi.org/10.3390/ijms22094701

Ejemplares similares

Pharmaceutical Induction of PGC-1α Promotes Retinal Pigment Epithelial Cell Metabolism and Protects against Oxidative Damage
por: Satish, Sangeeta, et al.
Publicado: (2018)

EMT and EndMT: Emerging Roles in Age-Related Macular Degeneration
por: Shu, Daisy Y., et al.
Publicado: (2020)

Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
por: Rosales, Mariana Aparecida Brunini, et al.
Publicado: (2019)

Correction: Loss of PGC-1α in RPE induces mesenchymal transition and promotes retinal degeneration
por: Rosales, Mariana Aparecida Brunini, et al.
Publicado: (2019)

Divergent Metabolomic Signatures of TGFβ2 and TNFα in the Induction of Retinal Epithelial-Mesenchymal Transition
por: Ng, Pei Qin, et al.
Publicado: (2023)

Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health
por: Karg, Margarete M., et al.
Publicado: (2023)

Dimethyl Fumarate Blocks Tumor Necrosis Factor-Alpha-Driven Inflammation and Metabolic Rewiring in the Retinal Pigment Epithelium
por: Shu, Daisy Y., et al.
Publicado: (2022)

Correction: Microglia preserve visual function in the aging retina by supporting retinal pigment epithelial health
por: Karg, Margarete M., et al.
Publicado: (2023)

TNFα induced by DNA-sensing in macrophage compromises retinal pigment epithelial (RPE) barrier function
por: Twarog, Michael, et al.
Publicado: (2023)

Identification of a synergistic interaction between endothelial cells and retinal pigment epithelium
por: Spencer, Carrie, et al.
Publicado: (2017)

PGC-1α Induces Human RPE Oxidative Metabolism and Antioxidant Capacity
por: Iacovelli, Jared, et al.
Publicado: (2016)

Proteome Landscape of Epithelial-to-Mesenchymal Transition (EMT) of Retinal Pigment Epithelium Shares Commonalities With Malignancy-Associated EMT
por: Sripathi, Srinivasa R., et al.
Publicado: (2021)

Novel NADPH oxidase inhibitor VAS2870 suppresses TGF-β-dependent epithelial-to-mesenchymal transition in retinal pigment epithelial cells
por: Yang, Jing, et al.
Publicado: (2018)

Heat treatment of retinal pigment epithelium induces production of elastic lamina components and antiangiogenic activity
por: Sekiyama, Eiichi, et al.
Publicado: (2012)

Complement activation contributes to subretinal fibrosis through the induction of epithelial-to-mesenchymal transition (EMT) in retinal pigment epithelial cells
por: Llorián-Salvador, María, et al.
Publicado: (2022)

Role of Epithelial-Mesenchymal Transition in Retinal Pigment Epithelium Dysfunction
por: Zhou, Mi, et al.
Publicado: (2020)

TGFβ Drives Metabolic Perturbations during Epithelial Mesenchymal Transition in Pancreatic Cancer: TGFβ Induced EMT in PDAC
por: Rajagopal, Meena U., et al.
Publicado: (2021)

Epithelial-Mesenchymal Transition and Senescence in the Retinal Pigment Epithelium of NFE2L2/PGC-1α Double Knock-Out Mice
por: Blasiak, Janusz, et al.
Publicado: (2021)

Retinal Pigment Epithelial Cell Line Suppression of Phagolysosome Activation
por: Taylor, AW, et al.
Publicado: (2015)

Ascorbate Suppresses VEGF Expression in Retinal Pigment Epithelial Cells
por: Sant, David W., et al.
Publicado: (2018)

Retinal Pigment Epithelial Cells Suppress Phagolysosome Activation in Macrophages
por: Wang, Eric, et al.
Publicado: (2017)

Nanoscopic Approach to Study the Early Stages of Epithelial to Mesenchymal Transition (EMT) of Human Retinal Pigment Epithelial (RPE) Cells In Vitro
por: Chtcheglova, Lilia A., et al.
Publicado: (2020)

Role of LINC01592 in TGF-β1-induced epithelial-mesenchymal transition of retinal pigment epithelial cells
por: Su, Ying, et al.
Publicado: (2021)

Autophagy resists EMT process to maintain retinal pigment epithelium homeostasis
por: Feng, Hao, et al.
Publicado: (2019)

αvβ5 Integrin/FAK/PGC-1α Pathway Confers Protective Effects on Retinal Pigment Epithelium
por: Roggia, Murilo F., et al.
Publicado: (2015)

Proteotoxic Stress Desensitizes TGF-beta Signaling Through Receptor Downregulation in Retinal Pigment Epithelial Cells
por: Tan, X., et al.
Publicado: (2017)

Gremlin mediates the TGF-β-induced induction of profibrogenic genes in human retinal pigment epithelial cells
por: Qin, Dong, et al.
Publicado: (2020)

TGF-β Is Required for Vascular Barrier Function, Endothelial Survival and Homeostasis of the Adult Microvasculature
por: Walshe, Tony E., et al.
Publicado: (2009)

Paraoxonase 2 Deficiency Causes Mitochondrial Dysfunction in Retinal Pigment Epithelial Cells and Retinal Degeneration in Mice
por: Sreekumar, Parameswaran Gangadharan, et al.
Publicado: (2023)

Serpentine retinal pigment epithelial tear
por: Maitray, Aditya, et al.
Publicado: (2021)

Human retinal pigment epithelial cells
por: Wang, Lei, et al.
Publicado: (2021)

Effectively Intervening Epithelial-Mesenchymal Transition of Retinal Pigment Epithelial Cells With a Combination of ROCK and TGF-β Signaling Inhibitors
por: Chen, Yi, et al.
Publicado: (2021)

Suppressive effect of AMP-activated protein kinase on the epithelial-mesenchymal transition in retinal pigment epithelial cells
por: Matoba, Ryo, et al.
Publicado: (2017)

Continuous exposure to non-lethal doses of sodium iodate induces retinal pigment epithelial cell dysfunction
por: Zhang, Xiao-Yu, et al.
Publicado: (2016)

Effect of bradykinin on TGF-β1-induced retinal pigment epithelial cell proliferation and extracellular matrix secretion
por: Cai, Wenting, et al.
Publicado: (2016)

Autophagy regulates TGF-β2-induced epithelial-mesenchymal transition in human retinal pigment epithelium cells
por: Wu, Jing, et al.
Publicado: (2018)

Interleukin‐2 induces extracellular matrix synthesis and TGF‐β2 expression in retinal pigment epithelial cells
por: Jing, Ruihua, et al.
Publicado: (2019)

PGC-1α regulates airway epithelial barrier dysfunction induced by house dust mite
por: Saito, Tsutomu, et al.
Publicado: (2021)

The Anti-Aging Hormone Klotho Promotes Retinal Pigment Epithelium Cell Viability and Metabolism by Activating the AMPK/PGC-1α Pathway
por: Zhou, Shuyan, et al.
Publicado: (2023)

Foveolar simple retinal pigment epithelial hamartoma
por: Pujari, Amar, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_ri1peepv2kristtnp1qc2e8cpm