Cargando…

Cancer-Associated Fibroblast-Derived IL-6 Determines Unfavorable Prognosis in Cholangiocarcinoma by Affecting Autophagy-Associated Chemoresponse

SIMPLE SUMMARY: We aimed to validate with clinical and molecular data the hypothesis that CAF infiltration and release of IL-6 predict poor prognosis in CCA patients following dysregulation of autophagy in cancer cells. Stromal IL-6 and cancer-cell-associated autophagy proteins were assayed by Tissu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Thongchot, Suyanee, Vidoni, Chiara, Ferraresi, Alessandra, Loilome, Watcharin, Khuntikeo, Narong, Sangkhamanon, Sakkarn, Titapun, Attapol, Isidoro, Ciro, Namwat, Nisana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124468/ https://www.ncbi.nlm.nih.gov/pubmed/33925189 http://dx.doi.org/10.3390/cancers13092134

Ejemplares similares

Suppression of 14-3-3ζ in cholangiocarcinoma cells inhibits proliferation through attenuated Akt activity, enhancing chemosensitivity to gemcitabine
por: Kittirat, Yingpinyapat, et al.
Publicado: (2018)

Upregulation of TCTP is associated with cholangiocarcinoma progression and metastasis
por: Phanthaphol, Nattaporn, et al.
Publicado: (2017)

Interleukin-6-derived cancer-associated fibroblasts activate STAT3 pathway contributing to gemcitabine resistance in cholangiocarcinoma
por: Kittirat, Yingpinyapat, et al.
Publicado: (2022)

Inhibitory effect of NVP-BKM120 on cholangiocarcinoma cell growth
por: Padthaisong, Sureerat, et al.
Publicado: (2018)

Chemotherapeutic resistant cholangiocarcinoma displayed distinct intratumoral microbial composition and metabolic profiles
por: Sitthirak, Sirinya, et al.
Publicado: (2022)

A panel of protein kinase high expression is associated with postoperative recurrence in cholangiocarcinoma
por: Padthaisong, Sureerat, et al.
Publicado: (2020)

In vitro and in vivo Anti-Tumor Effects of Pan-HER Inhibitor Varlitinib on Cholangiocarcinoma Cell Lines
por: Dokduang, Hasaya, et al.
Publicado: (2020)

Overexpression of a panel of cancer stem cell markers enhances the predictive capability of the progression and recurrence in the early stage cholangiocarcinoma
por: Padthaisong, Sureerat, et al.
Publicado: (2020)

Curative effect of xanthohumol supplementation during liver fluke-associated cholangiocarcinogenesis: Potential involvement of autophagy
por: Thongchot, Suyanee, et al.
Publicado: (2019)

In vitro and molecular chemosensitivity in human cholangiocarcinoma tissues
por: Suksawat, Manida, et al.
Publicado: (2019)

Lipidomic Analyses Uncover Apoptotic and Inhibitory Effects of Pyrvinium Pamoate on Cholangiocarcinoma Cells via Mitochondrial Membrane Potential Dysfunction
por: Kittirat, Yingpinyapat, et al.
Publicado: (2021)

CD44 modulates metabolic pathways and altered ROS-mediated Akt signal promoting cholangiocarcinoma progression
por: Thanee, Malinee, et al.
Publicado: (2021)

Diagnostic and Prognostic Value of Circulating Cell-Free DNA for Cholangiocarcinoma
por: Wintachai, Preawwalee, et al.
Publicado: (2021)

CD44 variant‐dependent redox status regulation in liver fluke‐associated cholangiocarcinoma: A target for cholangiocarcinoma treatment
por: Thanee, Malinee, et al.
Publicado: (2016)

Integration of global metabolomics and lipidomics approaches reveals the molecular mechanisms and the potential biomarkers for postoperative recurrence in early-stage cholangiocarcinoma
por: Padthaisong, Sureerat, et al.
Publicado: (2021)

Potential role of HIF-1-responsive microRNA210/HIF3 axis on gemcitabine resistance in cholangiocarcinoma cells
por: Silakit, Runglawan, et al.
Publicado: (2018)

Targeting Fatty Acid Synthase Modulates Metabolic Pathways and Inhibits Cholangiocarcinoma Cell Progression
por: Tomacha, Jittima, et al.
Publicado: (2021)

The impact of hypoxia and oxidative stress on proteo-metabolomic alterations of 3D cholangiocarcinoma models
por: Phukhum, Pimpawadee, et al.
Publicado: (2023)

Imbalanced adaptive responses associated with microsatellite instability in cholangiocarcinoma
por: Loilome, Watcharin, et al.
Publicado: (2017)

Sulfasalazine modifies metabolic profiles and enhances cisplatin chemosensitivity on cholangiocarcinoma cells in in vitro and in vivo models
por: Thanee, Malinee, et al.
Publicado: (2021)

Inhibition of endothelial nitric oxide synthase in cholangiocarcinoma cell lines – a new strategy for therapy
por: Suksawat, Manida, et al.
Publicado: (2018)

(1)H NMR fecal metabolic phenotyping of periductal fibrosis- and cholangiocarcinoma-specific metabotypes defining perturbation in gut microbial-host co-metabolism
por: Treeriya, Rujikorn, et al.
Publicado: (2023)

Progranulin modulates cholangiocarcinoma cell proliferation, apoptosis, and motility via the PI3K/pAkt pathway
por: Daya, Minerva, et al.
Publicado: (2018)

Prognostic Significance of Growth Pattern in Predicting Outcome of Opisthorchis viverrini-Associated Distal Cholangiocarcinoma in Thailand
por: Kunprom, Waritta, et al.
Publicado: (2022)

Zileuton suppresses cholangiocarcinoma cell proliferation and migration through inhibition of the Akt signaling pathway
por: Khophai, Sasikamon, et al.
Publicado: (2018)

Modification of the eighth AJCC/UICC staging system for perihilar cholangiocarcinoma: An alternative pathological staging system from cholangiocarcinoma-prevalent Northeast Thailand
por: Aphivatanasiri, Chaiwat, et al.
Publicado: (2022)

Metabolomic analyses uncover an inhibitory effect of niclosamide on mitochondrial membrane potential in cholangiocarcinoma cells
por: Kulthawatsiri, Thanaporn, et al.
Publicado: (2023)

Prognostic significance of tumor-infiltrating lymphocytes in predicting outcome of distal cholangiocarcinoma in Thailand
por: Intarawichian, Piyapharom, et al.
Publicado: (2022)

Serum IgG as a Marker for Opisthorchis viverrini-Associated Cholangiocarcinoma Correlated with HER2 Overexpression
por: Titapun, Attapol, et al.
Publicado: (2020)

Metabolic Phenotyping Predicts Gemcitabine and Cisplatin Chemosensitivity in Patients With Cholangiocarcinoma
por: Suksawat, Manida, et al.
Publicado: (2022)

Opisthorchiasis and cholangiocarcinoma in Southeast Asia: an unresolved problem
por: Hughes, Thomas, et al.
Publicado: (2017)

Current Perspectives on Opisthorchiasis Control and Cholangiocarcinoma Detection in Southeast Asia
por: Khuntikeo, Narong, et al.
Publicado: (2018)

Cohort profile: cholangiocarcinoma screening and care program (CASCAP)
por: Khuntikeo, Narong, et al.
Publicado: (2015)

Programmed Death-Ligand 1 (PD-L1) Expression Associated with a High Neutrophil/Lymphocyte Ratio in Cholangiocarcinoma
por: Sangkhamanon, Sakkarn, et al.
Publicado: (2017)

Evaluation of p53 and Its Target Gene Expression as Potential Biomarkers of Cholangiocarcinoma in Thai Patients
por: Puetkasichonpasutha, Janpen, et al.
Publicado: (2020)

Evaluation of anticancer potential of Thai medicinal herb extracts against cholangiocarcinoma cell lines
por: Promraksa, Bundit, et al.
Publicado: (2019)

A Comprehensive Public Health Conceptual Framework and Strategy to Effectively Combat Cholangiocarcinoma in Thailand
por: Khuntikeo, Narong, et al.
Publicado: (2016)

MR imaging findings of a patient with isolated intrahepatic splenosis mistaken for hepatocellular carcinoma
por: Somsap, Kulyada, et al.
Publicado: (2016)

Urine proteomics study reveals potential biomarkers for the differential diagnosis of cholangiocarcinoma and periductal fibrosis
por: Duangkumpha, Kassaporn, et al.
Publicado: (2019)

Teleconsultation ultrasonography: a new weapon to combat cholangiocarcinoma
por: Chamadol, Nittaya, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_genq2eqpq9t6p7ge5vdem9p2nn