Novel Seleno-Aspirinyl Compound AS-10 Induces Apoptosis, G1 Arrest of Pancreatic Ductal Adenocarcinoma Cells, Inhibits Their NF-κB Signaling, and Synergizes with Gemcitabine Cytotoxicity

Current available therapies for pancreatic ductal adenocarcinoma (PDAC) provide minimal overall survival benefits and cause severe adverse effects. We have identified a novel molecule AS-10, a selenazolidine-bis-aspirinyl derivative, that was two to three orders of magnitude more potent than aspirin...

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Detalles Bibliográficos
Autores principales: Karelia, Deepkamal N., Kim, Sangyub, K. Pandey, Manoj, Plano, Daniel, Amin, Shantu, Lu, Junxuan, Sharma, Arun K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124556/
https://www.ncbi.nlm.nih.gov/pubmed/34067020
http://dx.doi.org/10.3390/ijms22094966

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124556/
https://www.ncbi.nlm.nih.gov/pubmed/34067020
http://dx.doi.org/10.3390/ijms22094966

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