Preclinical Assessment Addressing Intravenous Administration of a [(68)Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution

It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [(68)Ga]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the...

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Autores principales: Mandiwana, Vusani, Kalombo, Lonji, Hayeshi, Rose, Zeevaart, Jan Rijn, Ebenhan, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124668/
https://www.ncbi.nlm.nih.gov/pubmed/33946599
http://dx.doi.org/10.3390/molecules26092650
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author Mandiwana, Vusani
Kalombo, Lonji
Hayeshi, Rose
Zeevaart, Jan Rijn
Ebenhan, Thomas
author_facet Mandiwana, Vusani
Kalombo, Lonji
Hayeshi, Rose
Zeevaart, Jan Rijn
Ebenhan, Thomas
author_sort Mandiwana, Vusani
collection PubMed
description It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [(68)Ga]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [(68)Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results.
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spelling pubmed-81246682021-05-17 Preclinical Assessment Addressing Intravenous Administration of a [(68)Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution Mandiwana, Vusani Kalombo, Lonji Hayeshi, Rose Zeevaart, Jan Rijn Ebenhan, Thomas Molecules Article It has been herein presented that a microemulsion, known to be an effective and safe drug delivery system following intravenous administration, can be loaded with traces of [(68)Ga]Ga-PSMA-617 without losing its properties or causing toxicity. Following tolerated IV injections the capability of the microemulsion in altering [(68)Ga]Ga-PSMA-617 distribution was presented at 120 min post injection based on its ex vivo biodistribution results. MDPI 2021-04-30 /pmc/articles/PMC8124668/ /pubmed/33946599 http://dx.doi.org/10.3390/molecules26092650 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mandiwana, Vusani
Kalombo, Lonji
Hayeshi, Rose
Zeevaart, Jan Rijn
Ebenhan, Thomas
Preclinical Assessment Addressing Intravenous Administration of a [(68)Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution
title Preclinical Assessment Addressing Intravenous Administration of a [(68)Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution
title_full Preclinical Assessment Addressing Intravenous Administration of a [(68)Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution
title_fullStr Preclinical Assessment Addressing Intravenous Administration of a [(68)Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution
title_full_unstemmed Preclinical Assessment Addressing Intravenous Administration of a [(68)Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution
title_short Preclinical Assessment Addressing Intravenous Administration of a [(68)Ga]Ga-PSMA-617 Microemulsion: Acute In Vivo Toxicity, Tolerability, PET Imaging, and Biodistribution
title_sort preclinical assessment addressing intravenous administration of a [(68)ga]ga-psma-617 microemulsion: acute in vivo toxicity, tolerability, pet imaging, and biodistribution
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124668/
https://www.ncbi.nlm.nih.gov/pubmed/33946599
http://dx.doi.org/10.3390/molecules26092650
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