Cross-TCR Antagonism Revealed by Optogenetically Tuning the Half-Life of the TCR Ligand Binding

Activation of T cells by agonistic peptide-MHC can be inhibited by antagonistic ones. However, the exact mechanism remains elusive. We used Jurkat cells expressing two different TCRs and tested whether stimulation of the endogenous TCR by agonistic anti-Vβ8 antibodies can be modulated by ligand-bind...

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Detalles Bibliográficos
Autores principales: Yousefi, Omid Sascha, Ruggieri, Matias, Idstein, Vincent, von Prillwitz, Kai Uwe, Herr, Laurenz A., Chalupsky, Julia, Köhn, Maja, Weber, Wilfried, Timmer, Jens, Schamel, Wolfgang W. A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124730/
https://www.ncbi.nlm.nih.gov/pubmed/34066527
http://dx.doi.org/10.3390/ijms22094920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124730/
https://www.ncbi.nlm.nih.gov/pubmed/34066527
http://dx.doi.org/10.3390/ijms22094920

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