ATRX Alteration Contributes to Tumor Growth and Immune Escape in Pleomorphic Sarcomas

SIMPLE SUMMARY: There is still no efficient systemic treatment for pleomorphic sarcomas. This study shows that 1/4 of them have an ATRX alteration that diminishes the immune response. This phenotype is related to the inhibition of mast cell recruitment upon ATRX alteration, which could be targeted t...

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Detalles Bibliográficos
Autores principales: Darmusey, Lucie, Pérot, Gaëlle, Thébault, Noémie, Le Guellec, Sophie, Desplat, Nelly, Gaston, Laëtitia, Delespaul, Lucile, Lesluyes, Tom, Darbo, Elodie, Gomez-Brouchet, Anne, Richard, Elodie, Baud, Jessica, Leroy, Laura, Coindre, Jean-Michel, Blay, Jean-Yves, Chibon, Frédéric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8124877/
https://www.ncbi.nlm.nih.gov/pubmed/33946962
http://dx.doi.org/10.3390/cancers13092151

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